Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthma

•The level of P2Y12R is upregulated in the lung tissues and inflammatory cells, and increased even more robustly compared to that of CysLTR1 and CysLTR2 in the asthma mouse model.•Montelukast, HAMI 3379 showed the cross-inhibitory effect on the expression levels of CysLTR1, CysLTR2, and P2Y12R. The...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2019-02, Vol.141, p.17-23
Hauptverfasser:	Trinh, Hoang Kim Tu, Suh, Dong-Hyeon, Nguyen, Thuy Van Thao, Choi, Youngwoo, Park, Hae-Sim, Shin, Yoo Seob
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Acetates - therapeutic use Animals Asthma Asthma - chemically induced Asthma - drug therapy Asthma - metabolism Clopidogrel Clopidogrel - pharmacology Clopidogrel - therapeutic use Cyclohexanecarboxylic Acids - pharmacology Cysteinyl leukotrienes receptor Disease Models, Animal Drug Therapy, Combination Eosinophils - drug effects Female Inflammation - drug therapy Interleukins - metabolism Leukotriene Antagonists - pharmacology Leukotriene Antagonists - therapeutic use Mice Mice, Inbred BALB C Montelukast Ovalbumin - pharmacology Phthalic Acids - pharmacology Purinergic P2Y Receptor Antagonists - pharmacology Purinergic P2Y Receptor Antagonists - therapeutic use Quinolines - pharmacology Quinolines - therapeutic use Receptors, Leukotriene - metabolism Receptors, Purinergic P2Y12 - metabolism Th2 Cells - drug effects Th2 Cells - metabolism
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