Risk Factors for Low CD4+ Count Recovery Despite Viral Suppression Among Participants Initiating Antiretroviral Treatment With CD4+ Counts > 500 Cells/mm3: Findings From the Strategic Timing of AntiRetroviral Therapy (START) Trial

Risk Factors for Low CD4+ Count Recovery Despite Viral Suppression Among Participants Initiating Antiretroviral Treatment With CD4+ Counts > 500 Cells/mm3: Findings From the Strategic Timing of AntiRetroviral Therapy (START) Trial

BACKGROUND:Low CD4 recovery among HIV-positive individuals who achieve virologic suppression is common but has not been studied among individuals initiating treatment at CD4 counts of >500 cells/mm. SETTING:United States, Africa, Asia, Europe and Israel, Australia, Latin America. METHODS:Among pa...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2019-05, Vol.81 (1), p.10-17
Hauptverfasser: Boatman, Jeffrey A, Baker, Jason V, Emery, Sean, Furrer, Hansjakob, Mushatt, David M, Sedláček, Dalibor, Lundgren, Jens D, Neaton, James D
Format: Artikel
Sprache:eng
Schlagworte:
Adult
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
CD4 antigen
CD4 Lymphocyte Count - statistics & numerical data
CD4-Positive T-Lymphocytes - drug effects
CD8 antigen
Dimers
Drug therapy
Female
HIV
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Logistic Models
Male
Recovery
Ribonucleic acid
Risk analysis
Risk Factors
RNA
Screening
Sex
Sex Factors
Sex ratio
Sexually transmitted diseases
Therapy
Treatment Failure
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Zusammenfassung:BACKGROUND:Low CD4 recovery among HIV-positive individuals who achieve virologic suppression is common but has not been studied among individuals initiating treatment at CD4 counts of >500 cells/mm. SETTING:United States, Africa, Asia, Europe and Israel, Australia, Latin America. METHODS:Among participants randomized to immediate antiretroviral therapy (ART) in the Strategic Timing of AntiRetroviral Therapy trial, low CD4 recovery was defined as a CD4 increase of
ISSN:1525-4135
1944-7884
DOI:10.1097/QAI.0000000000001967