Light-mediated copper-catalyzed phosphorus/halogen exchange in 1,1-difluoroalkylphosphonium salts

Light-mediated copper-catalyzed phosphorus/halogen exchange in 1,1-difluoroalkylphosphonium salts

A method for the assembly of the halodifluoromethyl group (CF2X, X = Cl, Br, I) is described. The reaction involves the light-mediated substitution of the triphenylphosphine by halide anions in readily accessible gem-difluorinated phosphonium salts.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (9), p.1314-1317
Hauptverfasser: Panferova, Liubov I, Levin, Vitalij V, Struchkova, Marina I, Dilman, Alexander D
Format: Artikel
Sprache:eng
Schlagworte:
NMR
Nuclear magnetic resonance
Substitution reactions
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Zusammenfassung:A method for the assembly of the halodifluoromethyl group (CF2X, X = Cl, Br, I) is described. The reaction involves the light-mediated substitution of the triphenylphosphine by halide anions in readily accessible gem-difluorinated phosphonium salts.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09115c