The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial
The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Level...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2019-07, Vol.48 (7), p.962-970 |
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| container_title | International journal of oral and maxillofacial surgery |
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| creator | Óbice, A.L.S. Correa, M.G. Feng, H.S. Ribeiro, F.V. Cirano, F.R. Casati, M.Z. Pimentel, S.P. |
| description | The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days. Inter-group comparisons indicated higher levels of EGF, BMP-9, ET-1, FGF, and PlGF in the test group after 30days (P |
| doi_str_mv | 10.1016/j.ijom.2018.12.012 |
| format | Article |
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Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days. Inter-group comparisons indicated higher levels of EGF, BMP-9, ET-1, FGF, and PlGF in the test group after 30days (P<0.05). PlGF levels were also higher in the test group after 60 days. In the test group, intra-group analysis revealed different levels of ET-1 and FGF between days 3 and 30, and days 3 and 60 (P<0.05); furthermore, VEGF levels were significantly higher on day 60 than on day 3 (P <0.05). In the control group, intra-group analysis demonstrated significantly different levels of ET-1, FGF, and PlGF between days 3 and 60 and of PlGF between days 14 and 60 (P<0.05). In conclusion, abutment surfaces treated with TiO2 influenced the levels of angiogenesis and bone-related markers.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2018.12.012</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>biological markers ; bone ; dental abutment ; dental implants ; protein array ; surface treatment</subject><ispartof>International journal of oral and maxillofacial surgery, 2019-07, Vol.48 (7), p.962-970</ispartof><rights>2019 International Association of Oral and Maxillofacial Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-397ca19f733b1d8c6da5cf8f222097dc34a9a72e0ff008fcad099d8fbcaef5823</citedby><cites>FETCH-LOGICAL-c333t-397ca19f733b1d8c6da5cf8f222097dc34a9a72e0ff008fcad099d8fbcaef5823</cites><orcidid>0000-0002-2697-620X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0901502719300013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Óbice, A.L.S.</creatorcontrib><creatorcontrib>Correa, M.G.</creatorcontrib><creatorcontrib>Feng, H.S.</creatorcontrib><creatorcontrib>Ribeiro, F.V.</creatorcontrib><creatorcontrib>Cirano, F.R.</creatorcontrib><creatorcontrib>Casati, M.Z.</creatorcontrib><creatorcontrib>Pimentel, S.P.</creatorcontrib><title>The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial</title><title>International journal of oral and maxillofacial surgery</title><description>The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days. Inter-group comparisons indicated higher levels of EGF, BMP-9, ET-1, FGF, and PlGF in the test group after 30days (P<0.05). PlGF levels were also higher in the test group after 60 days. In the test group, intra-group analysis revealed different levels of ET-1 and FGF between days 3 and 30, and days 3 and 60 (P<0.05); furthermore, VEGF levels were significantly higher on day 60 than on day 3 (P <0.05). In the control group, intra-group analysis demonstrated significantly different levels of ET-1, FGF, and PlGF between days 3 and 60 and of PlGF between days 14 and 60 (P<0.05). In conclusion, abutment surfaces treated with TiO2 influenced the levels of angiogenesis and bone-related markers.</description><subject>biological markers</subject><subject>bone</subject><subject>dental abutment</subject><subject>dental implants</subject><subject>protein array</subject><subject>surface treatment</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9UctOHDEQtCIiZSH5AU4-cplJ284y44gLQnlJSFw2Z6vXboM3nvFie4mSH8nv4tGGK6euflS3uoqxcwG9AHH5cdeHXZp6CWLshexByDdsJZTWHYCEE7YCDaJbgxzesdNSdgCg1Tis2L_NA_Ew7dFWnvyCIs6V4_ZQJ2qgHLJHS7xmwmPld6gPfBPuJE8z31MO3Qsp0hPFsqzB-T6ke5qphNISx7dppi5TxEqOT5h_US6fOfLcmmkKf1vVxjAHi7GdChjfs7ceY6EP_-MZ-_n1y-bme3d79-3HzfVtZ5VStVN6sCi0H5TaCjfaS4dr60cvpQQ9OKs-ocZBEngPMHqLDrR2o99aJL8epTpjF8e9-5weD1SqmUKxFNtDlA7FSDE0ocRa6jYqj6M2p1IyebPPof3yxwgwiwtmZxYXzOKCEdI0Fxrp6khqytBToGyKDTRbciGTrcal8Br9GbhJlHs</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Óbice, A.L.S.</creator><creator>Correa, M.G.</creator><creator>Feng, H.S.</creator><creator>Ribeiro, F.V.</creator><creator>Cirano, F.R.</creator><creator>Casati, M.Z.</creator><creator>Pimentel, S.P.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2697-620X</orcidid></search><sort><creationdate>201907</creationdate><title>The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial</title><author>Óbice, A.L.S. ; Correa, M.G. ; Feng, H.S. ; Ribeiro, F.V. ; Cirano, F.R. ; Casati, M.Z. ; Pimentel, S.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-397ca19f733b1d8c6da5cf8f222097dc34a9a72e0ff008fcad099d8fbcaef5823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>biological markers</topic><topic>bone</topic><topic>dental abutment</topic><topic>dental implants</topic><topic>protein array</topic><topic>surface treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Óbice, A.L.S.</creatorcontrib><creatorcontrib>Correa, M.G.</creatorcontrib><creatorcontrib>Feng, H.S.</creatorcontrib><creatorcontrib>Ribeiro, F.V.</creatorcontrib><creatorcontrib>Cirano, F.R.</creatorcontrib><creatorcontrib>Casati, M.Z.</creatorcontrib><creatorcontrib>Pimentel, S.P.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Óbice, A.L.S.</au><au>Correa, M.G.</au><au>Feng, H.S.</au><au>Ribeiro, F.V.</au><au>Cirano, F.R.</au><au>Casati, M.Z.</au><au>Pimentel, S.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><date>2019-07</date><risdate>2019</risdate><volume>48</volume><issue>7</issue><spage>962</spage><epage>970</epage><pages>962-970</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><abstract>The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days. Inter-group comparisons indicated higher levels of EGF, BMP-9, ET-1, FGF, and PlGF in the test group after 30days (P<0.05). PlGF levels were also higher in the test group after 60 days. In the test group, intra-group analysis revealed different levels of ET-1 and FGF between days 3 and 30, and days 3 and 60 (P<0.05); furthermore, VEGF levels were significantly higher on day 60 than on day 3 (P <0.05). In the control group, intra-group analysis demonstrated significantly different levels of ET-1, FGF, and PlGF between days 3 and 60 and of PlGF between days 14 and 60 (P<0.05). In conclusion, abutment surfaces treated with TiO2 influenced the levels of angiogenesis and bone-related markers.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.ijom.2018.12.012</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2697-620X</orcidid></addata></record> |
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| ispartof | International journal of oral and maxillofacial surgery, 2019-07, Vol.48 (7), p.962-970 |
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| source | Elsevier ScienceDirect Journals |
| subjects | biological markers bone dental abutment dental implants protein array surface treatment |
| title | The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial |
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