Mechanically robust and stretchable silk/hyaluronic acid hydrogels

[Display omitted] •Novel hyaluronic acid (HA) / silk fibroin (SF) hydrogels are prepared.•SF component significantly enhances the mechanical strength of SF/HA hydrogels.•Hydrogels have hybrid-crosslinked structure consisting of crosslinks and β-sheets.•They exhibit a wide range of tunable mechanical...

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Veröffentlicht in:Carbohydrate polymers 2019-03, Vol.208, p.413-420
Hauptverfasser: Tavsanli, Burak, Okay, Oguz
Format: Artikel
Sprache:eng
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Zusammenfassung:[Display omitted] •Novel hyaluronic acid (HA) / silk fibroin (SF) hydrogels are prepared.•SF component significantly enhances the mechanical strength of SF/HA hydrogels.•Hydrogels have hybrid-crosslinked structure consisting of crosslinks and β-sheets.•They exhibit a wide range of tunable mechanical and swelling properties. Combining the material and biological properties of hyaluronic acid (HA) and silk fibroin (SF) in a single hydrogel would expand the range of applications available to HA and SF individually. Here, we present a novel strategy to prepare mechanically robust and stretchable SF/HA hydrogels. The hydrogels were prepared from methacrylated HA (MeHA) and SF in aqueous solutions in the presence of a radical initiator. N, N-dimethylacrylamide (DMAA) monomer was also included into the reaction solution as a spacer to connect MeHA’s through their pendant vinyl groups. The presence of SF significantly enhances the mechanical strength of HA hydrogels due to its β-sheet domains acting as physical cross-links. The damage in SF network under large strain leads to a significant energy dissipation, which is responsible for the improved mechanical properties of SF/HA hydrogels.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2018.12.088