Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role

The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and the underlying mechanisms. The serum concentration of CST among 224 CAD p...

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Veröffentlicht in:	Atherosclerosis 2019-02, Vol.281, p.78-88
Hauptverfasser:	Chen, Yanjia, Wang, Xiaoqun, Yang, Chendie, Su, Xiuxiu, Yang, Wenbo, Dai, Yang, Han, Hui, Jiang, Jie, Lu, Lin, Wang, Haibo, Chen, Qiujing, Jin, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-converting enzyme 2 Animals Anti-Inflammatory Agents - pharmacology Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Biomarkers - blood Case-Control Studies Catestatin Cell Adhesion Molecules - metabolism Cells, Cultured Chromogranin A - blood Chromogranin A - pharmacology Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Cytokines - metabolism Disease Models, Animal Down-Regulation Female Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hypotensive peptide Inflammation Male Mice, Knockout, ApoE Peptide Fragments - blood Peptide Fragments - pharmacology Peptidyl-Dipeptidase A - metabolism Plaque, Atherosclerotic Severity of Illness Index
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Zusammenfassung:	The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and the underlying mechanisms. The serum concentration of CST among 224 CAD patients and 204 healthy controls was compared, and its association with atherosclerosis severity in 921 CAD patients was further analyzed. Compared to healthy subjects, serum CST concentration was lower in patients with CAD [1.14 (1.05–1.24) ng/mL vs. 2.15 (1.92–2.39) ng/mL, p
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2018.12.025