Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages

Growth differentiation factor-15 (GDF-15)/macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation and development of atherosclerosis and is highly expressed in macrophages (MΦ) of atherosclerotic lesions. Thus, we were interested in investigating the in...

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Veröffentlicht in:	Atherosclerosis 2019-02, Vol.281, p.128-136
Hauptverfasser:	Ackermann, Kathrin, Bonaterra, Gabriel A., Kinscherf, Ralf, Schwarz, Anja
Format:	Artikel
Sprache:	eng
Schlagworte:	ATG5 Autophagy Autophagy - drug effects Autophagy-Related Proteins - metabolism Foam Cells - drug effects Foam Cells - metabolism Foam Cells - pathology GDF-15 Growth Differentiation Factor 15 - genetics Growth Differentiation Factor 15 - metabolism Growth Differentiation Factor 15 - pharmacology Homeostasis Humans Lipid Metabolism - drug effects Lipoproteins, LDL - pharmacology oxLDL p62 Recombinant Proteins - metabolism THP-1 Cells
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