Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics

Directing GDNF-mediated neuronal signaling with proactively programmable cell-surface saccharide-free glycosaminoglycan mimetics

A significant barrier to harnessing the power of cell-surface glycosaminoglycans (GAGs) to modulate glial cell-line-derived neurotrophic factor (GDNF) signaling is the difficulty in accessing key GAG structures involved. Here, we report tailored GDNF signaling using synthetic polyproline-based GAG m...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (9), p.1259-1262
Hauptverfasser: Cai, Shuting, Lukamto, Daniel H, Toh, Jerry K C, Huber, Roland G, Bond, Peter J, Jee, Joo-Eun, Lim, Teck Chuan, Liu, Pei, Chen, Liwei, Qu, Qianqian Vicky, Lee, Su Seong, Lee, Song-Gil
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrates
Glycosaminoglycans
Signaling
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Zusammenfassung:A significant barrier to harnessing the power of cell-surface glycosaminoglycans (GAGs) to modulate glial cell-line-derived neurotrophic factor (GDNF) signaling is the difficulty in accessing key GAG structures involved. Here, we report tailored GDNF signaling using synthetic polyproline-based GAG mimetics (PGMs). PGMs deliver the much needed proactive programmability for GDNF recognition and effectively modulate GDNF-mediated neuronal processes in a cellular context.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09253b