LINC01857 as an oncogene regulates CREB1 activation by interacting with CREBBP in breast cancer

Breast cancer is a one of the most malignant threats among women worldwide. However, the mechanism underlying breast cancer development remains unclear. Long noncoding RNAs (lncRNAs) have been reported to participate in breast cancer. Whether lncRNA LINC01857 is involved in breast cancer requires in...

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Veröffentlicht in:	Journal of cellular physiology 2019-08, Vol.234 (8), p.14031-14039
Hauptverfasser:	Xiong, Youyi, Gu, Yuanting, Wang, Fang, Li, Lin, Zhu, Mingzhi, Wang, Nan, Mi, Hailong, Qiu, Xinguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis Apoptosis - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell adhesion & migration Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics CREB-Binding Protein - genetics CREB1 CREBBP Cyclic AMP Response Element-Binding Protein - genetics Female Gene Expression Regulation, Neoplastic - genetics H3K27Ac Heterografts Humans LINC01857 Mastectomy MCF-7 Cells Mice Middle Aged Oncogenes Oncogenes - genetics Prognosis progression Promoter Regions, Genetic - genetics RNA, Long Noncoding - genetics Transcription
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Zusammenfassung:	Breast cancer is a one of the most malignant threats among women worldwide. However, the mechanism underlying breast cancer development remains unclear. Long noncoding RNAs (lncRNAs) have been reported to participate in breast cancer. Whether lncRNA LINC01857 is involved in breast cancer requires investigation. In this study, we found that LINC01857 was highly expressed in breast cancer tissues and cells (p
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.28090