Sex‐based outcomes in type I thyroplasty for nonparalytic glottic incompetence
Objective Clinical outcomes for type I Gore‐Tex thyroplasty (GMT) for nonparalytic glottic incompetence (GI) have been reported in the literature. Given differences in male and female laryngeal anatomy, sex‐based outcomes should also be evaluated. We endeavored to evaluate sex‐specific post‐GMT voic...
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| Veröffentlicht in: | The Laryngoscope 2019-11, Vol.129 (11), p.2543-2548 |
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| creator | Farzal, Zainab Overton, Lewis J. Farquhar, Douglas R. Stephenson, Elizabeth D. Shah, Rupali N. Buckmire, Robert A. |
| description | Objective
Clinical outcomes for type I Gore‐Tex thyroplasty (GMT) for nonparalytic glottic incompetence (GI) have been reported in the literature. Given differences in male and female laryngeal anatomy, sex‐based outcomes should also be evaluated. We endeavored to evaluate sex‐specific post‐GMT voice outcomes.
Methods
We performed a retrospective review of patients undergoing GMT for nonparalytic GI. Multidimensional voice outcome measures including voice‐related quality of life (VRQOL), Glottal Function Index (GFI), and grade/roughness/breathiness/asthenia/strain (GRBAS) were analyzed at postoperative time frames: 0 to 3 months, 3 to 9 months, and 9 to 18 months.
Results
Eighty‐five subjects (43 females, 42 males) with mean age 53.5 undergoing GMT for nonparalytic GI from 2005 to 2017 met inclusion criteria. Etiologies included vocal fold hypomobility (N = 36, 42%), paresis (N = 18, 21%), vocal fold atrophy (N = 17, 20%), and scarring (N = 14, 17%). Females had significantly greater improvement on VRQOL at 0 to 3 months and 9 to 18 months timeframes compared to males, with mean change in VRQOL: 41.3 versus 22.4 (P = 0.0002) and 42.5 versus 20.8 (P = 0.002), respectively. Similarly, women had significantly greater improvement in GFI at 0 to 3 months follow‐up (mean difference − 10.8 vs. −4.9, respectively, P = 0.0002). There was no statistically significant sex difference in GRBAS at any follow‐up interval.
Conclusion
Following GMT, females had greater improvement in patient‐reported voice outcomes in the early postoperative period. No significant difference between sexes was noted in perceptual measures (GRBAS). Sex‐specific outcomes should be evaluated for clinical interventions to improve specificity of preoperative counseling.
Level of Evidence
4. Laryngoscope, 129:2543–2548, 2019 |
| doi_str_mv | 10.1002/lary.27770 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179351055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179351055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3570-e1db642ba4fa50c548a1332d1d7702b56b389cadf950b566b7b8e509ee009f033</originalsourceid><addsrcrecordid>eNp9kM1KxDAQx4Moun5cfAApeBGhOkmaTXuUxS9YUPwAPYW0nWqXblOTFu3NR_AZfRKzdvXgwdMwzG_-zPwI2aVwRAHYcaVtf8SklLBCRlRwGkZJIlbJyA95GAv2sEE2nZsBUMkFrJMNDmPOqEhG5PoW3z7fP1LtMA9M12Zmji4o66DtGwwug_a5t6aptGv7oDA2qE3daKurvi2z4Kky7aKWtV9rsMU6w22yVujK4c6ybpH7s9O7yUU4vTq_nJxMw4wLCSHSPB1HLNVRoQVkIoo15ZzlNPdvsFSMUx4nmc6LRIDvxqlMYxSQIAIkBXC-RQ6G3Maalw5dq-aly7CqdI2mc4pRmXBBQQiP7v9BZ6aztb9OMQ6SShqzyFOHA5VZ45zFQjW2nHu1ioJaeFYLz-rbs4f3lpFdOsf8F_0R6wE6AK9lhf0_UWp6cvM4hH4BkiWJFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2307171824</pqid></control><display><type>article</type><title>Sex‐based outcomes in type I thyroplasty for nonparalytic glottic incompetence</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Farzal, Zainab ; Overton, Lewis J. ; Farquhar, Douglas R. ; Stephenson, Elizabeth D. ; Shah, Rupali N. ; Buckmire, Robert A.</creator><creatorcontrib>Farzal, Zainab ; Overton, Lewis J. ; Farquhar, Douglas R. ; Stephenson, Elizabeth D. ; Shah, Rupali N. ; Buckmire, Robert A.</creatorcontrib><description>Objective
Clinical outcomes for type I Gore‐Tex thyroplasty (GMT) for nonparalytic glottic incompetence (GI) have been reported in the literature. Given differences in male and female laryngeal anatomy, sex‐based outcomes should also be evaluated. We endeavored to evaluate sex‐specific post‐GMT voice outcomes.
Methods
We performed a retrospective review of patients undergoing GMT for nonparalytic GI. Multidimensional voice outcome measures including voice‐related quality of life (VRQOL), Glottal Function Index (GFI), and grade/roughness/breathiness/asthenia/strain (GRBAS) were analyzed at postoperative time frames: 0 to 3 months, 3 to 9 months, and 9 to 18 months.
Results
Eighty‐five subjects (43 females, 42 males) with mean age 53.5 undergoing GMT for nonparalytic GI from 2005 to 2017 met inclusion criteria. Etiologies included vocal fold hypomobility (N = 36, 42%), paresis (N = 18, 21%), vocal fold atrophy (N = 17, 20%), and scarring (N = 14, 17%). Females had significantly greater improvement on VRQOL at 0 to 3 months and 9 to 18 months timeframes compared to males, with mean change in VRQOL: 41.3 versus 22.4 (P = 0.0002) and 42.5 versus 20.8 (P = 0.002), respectively. Similarly, women had significantly greater improvement in GFI at 0 to 3 months follow‐up (mean difference − 10.8 vs. −4.9, respectively, P = 0.0002). There was no statistically significant sex difference in GRBAS at any follow‐up interval.
Conclusion
Following GMT, females had greater improvement in patient‐reported voice outcomes in the early postoperative period. No significant difference between sexes was noted in perceptual measures (GRBAS). Sex‐specific outcomes should be evaluated for clinical interventions to improve specificity of preoperative counseling.
Level of Evidence
4. Laryngoscope, 129:2543–2548, 2019</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.27770</identifier><identifier>PMID: 30632159</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Clinical outcomes ; Female ; Gender differences ; glottic incompetence ; Glottis - physiopathology ; Glottis - surgery ; Humans ; Laryngeal Diseases - physiopathology ; Laryngeal Diseases - surgery ; Laryngoplasty - methods ; Laryngoplasty - statistics & numerical data ; Larynx ; Male ; Males ; Medialization thyroplasty ; Middle Aged ; Polytetrafluoroethylene ; Postoperative Period ; Quality of Life ; Retrospective Studies ; sex ; Sex Factors ; Treatment Outcome ; type I thyroplasty ; Vocal Cords ; Voice - physiology ; Voice Quality</subject><ispartof>The Laryngoscope, 2019-11, Vol.129 (11), p.2543-2548</ispartof><rights>2019 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3570-e1db642ba4fa50c548a1332d1d7702b56b389cadf950b566b7b8e509ee009f033</citedby><cites>FETCH-LOGICAL-c3570-e1db642ba4fa50c548a1332d1d7702b56b389cadf950b566b7b8e509ee009f033</cites><orcidid>0000-0002-3678-3989 ; 0000-0003-2357-7294</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.27770$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.27770$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30632159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farzal, Zainab</creatorcontrib><creatorcontrib>Overton, Lewis J.</creatorcontrib><creatorcontrib>Farquhar, Douglas R.</creatorcontrib><creatorcontrib>Stephenson, Elizabeth D.</creatorcontrib><creatorcontrib>Shah, Rupali N.</creatorcontrib><creatorcontrib>Buckmire, Robert A.</creatorcontrib><title>Sex‐based outcomes in type I thyroplasty for nonparalytic glottic incompetence</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objective
Clinical outcomes for type I Gore‐Tex thyroplasty (GMT) for nonparalytic glottic incompetence (GI) have been reported in the literature. Given differences in male and female laryngeal anatomy, sex‐based outcomes should also be evaluated. We endeavored to evaluate sex‐specific post‐GMT voice outcomes.
Methods
We performed a retrospective review of patients undergoing GMT for nonparalytic GI. Multidimensional voice outcome measures including voice‐related quality of life (VRQOL), Glottal Function Index (GFI), and grade/roughness/breathiness/asthenia/strain (GRBAS) were analyzed at postoperative time frames: 0 to 3 months, 3 to 9 months, and 9 to 18 months.
Results
Eighty‐five subjects (43 females, 42 males) with mean age 53.5 undergoing GMT for nonparalytic GI from 2005 to 2017 met inclusion criteria. Etiologies included vocal fold hypomobility (N = 36, 42%), paresis (N = 18, 21%), vocal fold atrophy (N = 17, 20%), and scarring (N = 14, 17%). Females had significantly greater improvement on VRQOL at 0 to 3 months and 9 to 18 months timeframes compared to males, with mean change in VRQOL: 41.3 versus 22.4 (P = 0.0002) and 42.5 versus 20.8 (P = 0.002), respectively. Similarly, women had significantly greater improvement in GFI at 0 to 3 months follow‐up (mean difference − 10.8 vs. −4.9, respectively, P = 0.0002). There was no statistically significant sex difference in GRBAS at any follow‐up interval.
Conclusion
Following GMT, females had greater improvement in patient‐reported voice outcomes in the early postoperative period. No significant difference between sexes was noted in perceptual measures (GRBAS). Sex‐specific outcomes should be evaluated for clinical interventions to improve specificity of preoperative counseling.
Level of Evidence
4. Laryngoscope, 129:2543–2548, 2019</description><subject>Adult</subject><subject>Aged</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Gender differences</subject><subject>glottic incompetence</subject><subject>Glottis - physiopathology</subject><subject>Glottis - surgery</subject><subject>Humans</subject><subject>Laryngeal Diseases - physiopathology</subject><subject>Laryngeal Diseases - surgery</subject><subject>Laryngoplasty - methods</subject><subject>Laryngoplasty - statistics & numerical data</subject><subject>Larynx</subject><subject>Male</subject><subject>Males</subject><subject>Medialization thyroplasty</subject><subject>Middle Aged</subject><subject>Polytetrafluoroethylene</subject><subject>Postoperative Period</subject><subject>Quality of Life</subject><subject>Retrospective Studies</subject><subject>sex</subject><subject>Sex Factors</subject><subject>Treatment Outcome</subject><subject>type I thyroplasty</subject><subject>Vocal Cords</subject><subject>Voice - physiology</subject><subject>Voice Quality</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KxDAQx4Moun5cfAApeBGhOkmaTXuUxS9YUPwAPYW0nWqXblOTFu3NR_AZfRKzdvXgwdMwzG_-zPwI2aVwRAHYcaVtf8SklLBCRlRwGkZJIlbJyA95GAv2sEE2nZsBUMkFrJMNDmPOqEhG5PoW3z7fP1LtMA9M12Zmji4o66DtGwwug_a5t6aptGv7oDA2qE3daKurvi2z4Kky7aKWtV9rsMU6w22yVujK4c6ybpH7s9O7yUU4vTq_nJxMw4wLCSHSPB1HLNVRoQVkIoo15ZzlNPdvsFSMUx4nmc6LRIDvxqlMYxSQIAIkBXC-RQ6G3Maalw5dq-aly7CqdI2mc4pRmXBBQQiP7v9BZ6aztb9OMQ6SShqzyFOHA5VZ45zFQjW2nHu1ioJaeFYLz-rbs4f3lpFdOsf8F_0R6wE6AK9lhf0_UWp6cvM4hH4BkiWJFA</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Farzal, Zainab</creator><creator>Overton, Lewis J.</creator><creator>Farquhar, Douglas R.</creator><creator>Stephenson, Elizabeth D.</creator><creator>Shah, Rupali N.</creator><creator>Buckmire, Robert A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3678-3989</orcidid><orcidid>https://orcid.org/0000-0003-2357-7294</orcidid></search><sort><creationdate>201911</creationdate><title>Sex‐based outcomes in type I thyroplasty for nonparalytic glottic incompetence</title><author>Farzal, Zainab ; Overton, Lewis J. ; Farquhar, Douglas R. ; Stephenson, Elizabeth D. ; Shah, Rupali N. ; Buckmire, Robert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3570-e1db642ba4fa50c548a1332d1d7702b56b389cadf950b566b7b8e509ee009f033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Clinical outcomes</topic><topic>Female</topic><topic>Gender differences</topic><topic>glottic incompetence</topic><topic>Glottis - physiopathology</topic><topic>Glottis - surgery</topic><topic>Humans</topic><topic>Laryngeal Diseases - physiopathology</topic><topic>Laryngeal Diseases - surgery</topic><topic>Laryngoplasty - methods</topic><topic>Laryngoplasty - statistics & numerical data</topic><topic>Larynx</topic><topic>Male</topic><topic>Males</topic><topic>Medialization thyroplasty</topic><topic>Middle Aged</topic><topic>Polytetrafluoroethylene</topic><topic>Postoperative Period</topic><topic>Quality of Life</topic><topic>Retrospective Studies</topic><topic>sex</topic><topic>Sex Factors</topic><topic>Treatment Outcome</topic><topic>type I thyroplasty</topic><topic>Vocal Cords</topic><topic>Voice - physiology</topic><topic>Voice Quality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farzal, Zainab</creatorcontrib><creatorcontrib>Overton, Lewis J.</creatorcontrib><creatorcontrib>Farquhar, Douglas R.</creatorcontrib><creatorcontrib>Stephenson, Elizabeth D.</creatorcontrib><creatorcontrib>Shah, Rupali N.</creatorcontrib><creatorcontrib>Buckmire, Robert A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farzal, Zainab</au><au>Overton, Lewis J.</au><au>Farquhar, Douglas R.</au><au>Stephenson, Elizabeth D.</au><au>Shah, Rupali N.</au><au>Buckmire, Robert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex‐based outcomes in type I thyroplasty for nonparalytic glottic incompetence</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2019-11</date><risdate>2019</risdate><volume>129</volume><issue>11</issue><spage>2543</spage><epage>2548</epage><pages>2543-2548</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objective
Clinical outcomes for type I Gore‐Tex thyroplasty (GMT) for nonparalytic glottic incompetence (GI) have been reported in the literature. Given differences in male and female laryngeal anatomy, sex‐based outcomes should also be evaluated. We endeavored to evaluate sex‐specific post‐GMT voice outcomes.
Methods
We performed a retrospective review of patients undergoing GMT for nonparalytic GI. Multidimensional voice outcome measures including voice‐related quality of life (VRQOL), Glottal Function Index (GFI), and grade/roughness/breathiness/asthenia/strain (GRBAS) were analyzed at postoperative time frames: 0 to 3 months, 3 to 9 months, and 9 to 18 months.
Results
Eighty‐five subjects (43 females, 42 males) with mean age 53.5 undergoing GMT for nonparalytic GI from 2005 to 2017 met inclusion criteria. Etiologies included vocal fold hypomobility (N = 36, 42%), paresis (N = 18, 21%), vocal fold atrophy (N = 17, 20%), and scarring (N = 14, 17%). Females had significantly greater improvement on VRQOL at 0 to 3 months and 9 to 18 months timeframes compared to males, with mean change in VRQOL: 41.3 versus 22.4 (P = 0.0002) and 42.5 versus 20.8 (P = 0.002), respectively. Similarly, women had significantly greater improvement in GFI at 0 to 3 months follow‐up (mean difference − 10.8 vs. −4.9, respectively, P = 0.0002). There was no statistically significant sex difference in GRBAS at any follow‐up interval.
Conclusion
Following GMT, females had greater improvement in patient‐reported voice outcomes in the early postoperative period. No significant difference between sexes was noted in perceptual measures (GRBAS). Sex‐specific outcomes should be evaluated for clinical interventions to improve specificity of preoperative counseling.
Level of Evidence
4. Laryngoscope, 129:2543–2548, 2019</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30632159</pmid><doi>10.1002/lary.27770</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3678-3989</orcidid><orcidid>https://orcid.org/0000-0003-2357-7294</orcidid></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Aged Clinical outcomes Female Gender differences glottic incompetence Glottis - physiopathology Glottis - surgery Humans Laryngeal Diseases - physiopathology Laryngeal Diseases - surgery Laryngoplasty - methods Laryngoplasty - statistics & numerical data Larynx Male Males Medialization thyroplasty Middle Aged Polytetrafluoroethylene Postoperative Period Quality of Life Retrospective Studies sex Sex Factors Treatment Outcome type I thyroplasty Vocal Cords Voice - physiology Voice Quality |
| title | Sex‐based outcomes in type I thyroplasty for nonparalytic glottic incompetence |
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