Significant relationship between the LAT1 expression pattern and chemoresistance in ovarian clear cell carcinoma

L-type amino acid transporter 1 (LAT1) is a Na + -independent neutral amino acid transporter that plays a key role in cancer cell growth and survival. To determine the significance of LAT1 in prognosis and resistance to chemotherapy in ovarian carcinoma, we investigated the LAT1 expression in 245 ov...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2019-06, Vol.474 (6), p.701-710
Hauptverfasser:	Sato, Kimiya, Miyamoto, Morikazu, Takano, Masashi, Furuya, Kenichi, Tsuda, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - metabolism Adenocarcinoma, Clear Cell - pathology Adult Aged Amino acids Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell survival Chemoresistance Chemotherapy Drug Resistance, Neoplasm - physiology Female Humans Immunohistochemistry Immunohistochemistry - methods Large Neutral Amino Acid-Transporter 1 - metabolism Medical prognosis Medicine Medicine & Public Health Middle Aged Multivariate analysis Neoplasm Staging - methods Original Article Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - diagnosis Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pathology Patients Prognosis Rank tests Surgery
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Zusammenfassung:	L-type amino acid transporter 1 (LAT1) is a Na + -independent neutral amino acid transporter that plays a key role in cancer cell growth and survival. To determine the significance of LAT1 in prognosis and resistance to chemotherapy in ovarian carcinoma, we investigated the LAT1 expression in 245 ovarian carcinoma patients by immunohistochemistry using tissue microarray. High expression of LAT1 was detected in 85 (34.7%) patients. The ratio of high expression of LAT1 was significantly high in clear cell carcinoma and low in serous carcinoma compared to other histological types ( P
ISSN:	0945-6317 1432-2307
DOI:	10.1007/s00428-019-02520-0