Triple-Bond Insertion Triggers Highly Regioselective 1,4-Aminomethylamination of 1,3-Enynes with Aminals Enabled by Pd-Catalyzed C–N Bond Activation

Triple-Bond Insertion Triggers Highly Regioselective 1,4-Aminomethylamination of 1,3-Enynes with Aminals Enabled by Pd-Catalyzed C–N Bond Activation

A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage of C–N bond activation has been reported. The reaction proceeds under mild reaction conditions and can be performed under lower catalyst loading (0.1 mol %) with high...

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Veröffentlicht in:Organic letters 2019-01, Vol.21 (2), p.535-539
Hauptverfasser: Zhang, Yanchen, Yu, Bangkui, Gao, Binjian, Zhang, Tianze, Huang, Hanmin
Format: Artikel
Sprache:eng
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Zusammenfassung:A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage of C–N bond activation has been reported. The reaction proceeds under mild reaction conditions and can be performed under lower catalyst loading (0.1 mol %) with high efficiency and broad substrate scope.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b03847