Clinical Significance of Matrix Metalloproteinases in Blood Plasma of Patients with Gastric Cancer

Plasma levels of MMP-2, MMP-7, and MMP-9 and their tissue inhibitor TIMP-2 were measured in 89 patients with gastric cancer and the relationship between these parameters and the main clinical morphological characteristics of the disease was analyzed. Plasma levels of the proteins were measured using...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-01, Vol.166 (3), p.373-376
Hauptverfasser:	Kushlinskii, N. E., Gershtein, E. S., Ivannikov, A. A., Davydov, M. M., Chang, V. L., Ognerubov, N. A., Stilidi, I. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Clinical significance Enzyme-linked immunosorbent assay Gastric cancer Gelatinase A Gelatinase B Histogenesis Internal Medicine Laboratory Medicine Matrilysin Medical prognosis Morphology Multivariate analysis Oncology Pathology Patients Physical characteristics Plasma Plasma levels Survival Tissue inhibitor of metalloproteinase 2 Tumors
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Zusammenfassung:	Plasma levels of MMP-2, MMP-7, and MMP-9 and their tissue inhibitor TIMP-2 were measured in 89 patients with gastric cancer and the relationship between these parameters and the main clinical morphological characteristics of the disease was analyzed. Plasma levels of the proteins were measured using standard direct ELISA kits. The level of MMP-7 in patients with gastric cancer was significantly higher than in the control group (medians 2.7 and 1.2 ng/ml, respectively; p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04353-y