SLAMF1/CD150 in hematologic malignancies: Silent marker or active player?

SLAMF1/CD150 receptor is a founder of signaling lymphocyte activation molecule (SLAM) family of cell-surface receptors. It is widely expressed on cells within hematopoietic system. In hematologic malignancies CD150 cell surface expression is restricted to cutaneous T-cell lymphomas, few types of B-cell non-Hodgkin's lymphoma, near half of cases of chronic lymphocytic leukemia, Hodgkin's lymphoma, and multiple myeloma. Differential expression among various types of hematological malignancies allows considering CD150 as diagnostical and potential prognostic marker. Moreover, CD150 may be a target for antibody-based or measles virus oncolytic therapy. Due to CD150 signaling properties it is involved in regulation of malignant cell fate decision and tumor microenvironment in Hodgkin's lymphoma and chronic lymphocytic leukemia. This review summarizes evidence for the important role of CD150 in pathogenesis of hematologic malignancies. •CD150 expression on neoplastic cells in hematologic malignancies is distinct from their normal analogues.•CD150 mediates signaling in normal and malignant hematopoietic cells.•CD150 is a potential target for therapeutic intervention in leukemias and lymphomas.•CD150 is an active player in Hodgkin lymphoma and chronic lymphocytic leukemia pathobiology.