Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats

This study investigated the role of melatonin (MLT) on adrenal gland toxicity induced by bisphenol A (BPA). Adult male rats were divided into four groups of seven animals each: Group I (control) received oral 0.2 ml canola oil; group II received intra-peritoneal 10 mg/kg BW/day MLT; and group III re...

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Veröffentlicht in:	Environmental science and pollution research international 2019-02, Vol.26 (6), p.5971-5982
Hauptverfasser:	Olukole, Samuel Gbadebo, Lanipekun, Damilare Olaniyi, Ola-Davies, Eunice Olufunke, Oke, Bankole Olusiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adrenal glands Adrenocorticotropic hormone Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bisphenol A Canola oil Corticosterone Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Hyperplasia Lipid peroxidation Lipids Melatonin Muscles Peritoneum Peroxidation Proteins Research Article Rodents Toxicity Vimentin Waste Water Technology Water Management Water Pollution Control
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Zusammenfassung:	This study investigated the role of melatonin (MLT) on adrenal gland toxicity induced by bisphenol A (BPA). Adult male rats were divided into four groups of seven animals each: Group I (control) received oral 0.2 ml canola oil; group II received intra-peritoneal 10 mg/kg BW/day MLT; and group III received oral BPA (10 mg/kg BW/day). Group IV rats were treated with same dose of BPA as group III with a concomitant intra-peritoneal 10 mg/kg BW/day MLT. All treatments lasted for 14 days. BPA significantly increased ( P
ISSN:	0944-1344 1614-7499
DOI:	10.1007/s11356-018-4024-5