A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children
We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D 3 , 722 mg docosahexaenoic acid, both, or placebo. O...
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| Veröffentlicht in: | Journal of autism and developmental disorders 2019-05, Vol.49 (5), p.1778-1794 |
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| container_title | Journal of autism and developmental disorders |
| container_volume | 49 |
| creator | Mazahery, Hajar Conlon, Cathryn A. Beck, Kathryn L. Mugridge, Owen Kruger, Marlena C. Stonehouse, Welma Camargo, Carlos A. Meyer, Barbara J. Tsang, Bobby Jones, Beatrix von Hurst, Pamela R. |
| description | We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D
3
, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (
P
= 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (
P
|
| doi_str_mv | 10.1007/s10803-018-3860-y |
| format | Article |
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3
, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (
P
= 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (
P
< 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made.</description><identifier>ISSN: 0162-3257</identifier><identifier>EISSN: 1573-3432</identifier><identifier>DOI: 10.1007/s10803-018-3860-y</identifier><identifier>PMID: 30607782</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Autism ; Autistic children ; Behavioral Science and Psychology ; Biochemistry ; Care and treatment ; Child and School Psychology ; Children ; Communication Skills ; Diet therapy ; Dietary supplements ; Docosahexaenoic acid ; Drug Therapy ; Efficacy ; Fatty acids ; Food and nutrition ; Health aspects ; Information processing ; Interpersonal Competence ; Intervention ; Neurosciences ; Nutrition ; Olfaction ; Omega 3 fatty acids ; Original Paper ; Outcomes of Treatment ; Pediatric research ; Pediatrics ; Pervasive Developmental Disorders ; Polyunsaturated fatty acids ; Psychology ; Psychomotor Skills ; Public Health ; Responsiveness ; Sensory Integration ; Sensory processes ; Social perception ; Standard Progressive Matrices ; Symptoms (Individual Disorders) ; Taste ; Toddlers ; Vitamin D ; Vitamin D3 ; Young Children</subject><ispartof>Journal of autism and developmental disorders, 2019-05, Vol.49 (5), p.1778-1794</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Journal of Autism and Developmental Disorders is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-12cc8c075f62a1c4e0215c40d31e3cc1e1fd0572e5e866e9e74b3dc7a1e238a63</citedby><cites>FETCH-LOGICAL-c533t-12cc8c075f62a1c4e0215c40d31e3cc1e1fd0572e5e866e9e74b3dc7a1e238a63</cites><orcidid>0000-0002-3743-2152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10803-018-3860-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10803-018-3860-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,12826,27903,27904,30978,41467,42536,51298</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ1213603$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30607782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mazahery, Hajar</creatorcontrib><creatorcontrib>Conlon, Cathryn A.</creatorcontrib><creatorcontrib>Beck, Kathryn L.</creatorcontrib><creatorcontrib>Mugridge, Owen</creatorcontrib><creatorcontrib>Kruger, Marlena C.</creatorcontrib><creatorcontrib>Stonehouse, Welma</creatorcontrib><creatorcontrib>Camargo, Carlos A.</creatorcontrib><creatorcontrib>Meyer, Barbara J.</creatorcontrib><creatorcontrib>Tsang, Bobby</creatorcontrib><creatorcontrib>Jones, Beatrix</creatorcontrib><creatorcontrib>von Hurst, Pamela R.</creatorcontrib><title>A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children</title><title>Journal of autism and developmental disorders</title><addtitle>J Autism Dev Disord</addtitle><addtitle>J Autism Dev Disord</addtitle><description>We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D
3
, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (
P
= 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (
P
< 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made.</description><subject>Autism</subject><subject>Autistic children</subject><subject>Behavioral Science and Psychology</subject><subject>Biochemistry</subject><subject>Care and treatment</subject><subject>Child and School Psychology</subject><subject>Children</subject><subject>Communication Skills</subject><subject>Diet therapy</subject><subject>Dietary supplements</subject><subject>Docosahexaenoic acid</subject><subject>Drug Therapy</subject><subject>Efficacy</subject><subject>Fatty acids</subject><subject>Food and nutrition</subject><subject>Health aspects</subject><subject>Information processing</subject><subject>Interpersonal Competence</subject><subject>Intervention</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Olfaction</subject><subject>Omega 3 fatty acids</subject><subject>Original Paper</subject><subject>Outcomes of Treatment</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Pervasive Developmental Disorders</subject><subject>Polyunsaturated fatty acids</subject><subject>Psychology</subject><subject>Psychomotor Skills</subject><subject>Public Health</subject><subject>Responsiveness</subject><subject>Sensory Integration</subject><subject>Sensory processes</subject><subject>Social perception</subject><subject>Standard Progressive Matrices</subject><subject>Symptoms (Individual Disorders)</subject><subject>Taste</subject><subject>Toddlers</subject><subject>Vitamin D</subject><subject>Vitamin D3</subject><subject>Young 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Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children</title><author>Mazahery, Hajar ; Conlon, Cathryn A. ; Beck, Kathryn L. ; Mugridge, Owen ; Kruger, Marlena C. ; Stonehouse, Welma ; Camargo, Carlos A. ; Meyer, Barbara J. ; Tsang, Bobby ; Jones, Beatrix ; von Hurst, Pamela R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-12cc8c075f62a1c4e0215c40d31e3cc1e1fd0572e5e866e9e74b3dc7a1e238a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Autism</topic><topic>Autistic children</topic><topic>Behavioral Science and Psychology</topic><topic>Biochemistry</topic><topic>Care and treatment</topic><topic>Child and School Psychology</topic><topic>Children</topic><topic>Communication Skills</topic><topic>Diet therapy</topic><topic>Dietary supplements</topic><topic>Docosahexaenoic acid</topic><topic>Drug Therapy</topic><topic>Efficacy</topic><topic>Fatty acids</topic><topic>Food and nutrition</topic><topic>Health aspects</topic><topic>Information processing</topic><topic>Interpersonal Competence</topic><topic>Intervention</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Olfaction</topic><topic>Omega 3 fatty acids</topic><topic>Original Paper</topic><topic>Outcomes of Treatment</topic><topic>Pediatric research</topic><topic>Pediatrics</topic><topic>Pervasive Developmental Disorders</topic><topic>Polyunsaturated fatty acids</topic><topic>Psychology</topic><topic>Psychomotor Skills</topic><topic>Public Health</topic><topic>Responsiveness</topic><topic>Sensory Integration</topic><topic>Sensory processes</topic><topic>Social perception</topic><topic>Standard Progressive Matrices</topic><topic>Symptoms (Individual Disorders)</topic><topic>Taste</topic><topic>Toddlers</topic><topic>Vitamin D</topic><topic>Vitamin D3</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazahery, Hajar</creatorcontrib><creatorcontrib>Conlon, Cathryn A.</creatorcontrib><creatorcontrib>Beck, Kathryn L.</creatorcontrib><creatorcontrib>Mugridge, Owen</creatorcontrib><creatorcontrib>Kruger, Marlena C.</creatorcontrib><creatorcontrib>Stonehouse, Welma</creatorcontrib><creatorcontrib>Camargo, Carlos A.</creatorcontrib><creatorcontrib>Meyer, Barbara J.</creatorcontrib><creatorcontrib>Tsang, Bobby</creatorcontrib><creatorcontrib>Jones, Beatrix</creatorcontrib><creatorcontrib>von Hurst, Pamela R.</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education 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disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazahery, Hajar</au><au>Conlon, Cathryn A.</au><au>Beck, Kathryn L.</au><au>Mugridge, Owen</au><au>Kruger, Marlena C.</au><au>Stonehouse, Welma</au><au>Camargo, Carlos A.</au><au>Meyer, Barbara J.</au><au>Tsang, Bobby</au><au>Jones, Beatrix</au><au>von Hurst, Pamela R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ1213603</ericid><atitle>A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children</atitle><jtitle>Journal of autism and developmental disorders</jtitle><stitle>J Autism Dev Disord</stitle><addtitle>J Autism Dev Disord</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>49</volume><issue>5</issue><spage>1778</spage><epage>1794</epage><pages>1778-1794</pages><issn>0162-3257</issn><eissn>1573-3432</eissn><abstract>We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D
3
, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (
P
= 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (
P
< 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30607782</pmid><doi>10.1007/s10803-018-3860-y</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-3743-2152</orcidid></addata></record> |
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| identifier | ISSN: 0162-3257 |
| ispartof | Journal of autism and developmental disorders, 2019-05, Vol.49 (5), p.1778-1794 |
| issn | 0162-3257 1573-3432 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2164103514 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Education Source; Springer Nature - Complete Springer Journals |
| subjects | Autism Autistic children Behavioral Science and Psychology Biochemistry Care and treatment Child and School Psychology Children Communication Skills Diet therapy Dietary supplements Docosahexaenoic acid Drug Therapy Efficacy Fatty acids Food and nutrition Health aspects Information processing Interpersonal Competence Intervention Neurosciences Nutrition Olfaction Omega 3 fatty acids Original Paper Outcomes of Treatment Pediatric research Pediatrics Pervasive Developmental Disorders Polyunsaturated fatty acids Psychology Psychomotor Skills Public Health Responsiveness Sensory Integration Sensory processes Social perception Standard Progressive Matrices Symptoms (Individual Disorders) Taste Toddlers Vitamin D Vitamin D3 Young Children |
| title | A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children |
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