A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children

We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D 3 , 722 mg docosahexaenoic acid, both, or placebo. O...

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Veröffentlicht in:	Journal of autism and developmental disorders 2019-05, Vol.49 (5), p.1778-1794
Hauptverfasser:	Mazahery, Hajar, Conlon, Cathryn A., Beck, Kathryn L., Mugridge, Owen, Kruger, Marlena C., Stonehouse, Welma, Camargo, Carlos A., Meyer, Barbara J., Tsang, Bobby, Jones, Beatrix, von Hurst, Pamela R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism Autistic children Behavioral Science and Psychology Biochemistry Care and treatment Child and School Psychology Children Communication Skills Diet therapy Dietary supplements Docosahexaenoic acid Drug Therapy Efficacy Fatty acids Food and nutrition Health aspects Information processing Interpersonal Competence Intervention Neurosciences Nutrition Olfaction Omega 3 fatty acids Original Paper Outcomes of Treatment Pediatric research Pediatrics Pervasive Developmental Disorders Polyunsaturated fatty acids Psychology Psychomotor Skills Public Health Responsiveness Sensory Integration Sensory processes Social perception Standard Progressive Matrices Symptoms (Individual Disorders) Taste Toddlers Vitamin D Vitamin D3 Young Children
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Zusammenfassung:	We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5–8.0 years) received daily 2000 IU vitamin D 3 , 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements ( P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements ( P
ISSN:	0162-3257 1573-3432
DOI:	10.1007/s10803-018-3860-y