HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

The first chromogenic substrate for Aspergillus oryzae acid protease, 'HAP-01', was successfully developed after evaluating the substrate specificity of the enzyme. Furthermore, with HAP-01, digestion-triggered chromophore release was employed as a novel chromogenic technique.

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Veröffentlicht in:Organic & biomolecular chemistry 2019-01, Vol.17 (4), p.776-779
Hauptverfasser: Yoshiya, Taku, Yamashita, Nobuo, Tsuda, Shugo, Oohigashi, Koushou, Masuda, Shun, Kubodera, Takafumi, Akashi, Takahito
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Aspergillus oryzae
Aspergillus oryzae - enzymology
Chromophores
Fungal Proteins - metabolism
Hydrogen-Ion Concentration
Nitrophenols - chemistry
Peptide Hydrolases - metabolism
Protease
Pyridines
Pyrimidines
Substrate Specificity
Substrates
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Beschreibung
Zusammenfassung:The first chromogenic substrate for Aspergillus oryzae acid protease, 'HAP-01', was successfully developed after evaluating the substrate specificity of the enzyme. Furthermore, with HAP-01, digestion-triggered chromophore release was employed as a novel chromogenic technique.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02766h