Expression of pro‐inflammatory cytokines and mediators induced by Bisphenol A via ERK‐NFκB and JAK1/2‐STAT3 pathways in macrophages

Expression of pro‐inflammatory cytokines and mediators induced by Bisphenol A via ERK‐NFκB and JAK1/2‐STAT3 pathways in macrophages

Macrophages not only play an important role in the innate immune response but also participate in many inflammatory and infectious diseases including asthma, diabetes, obesity, cardiovascular diseases, and cancers. Bisphenol A (BPA) is the most commonly used component for plastic products. However,...

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Veröffentlicht in:Environmental toxicology 2019-04, Vol.34 (4), p.486-494
Hauptverfasser: Huang, Fu‐Mei, Chang, Yu‐Chao, Lee, Shiuan‐Shinn, Yang, Ming‐Ling, Kuan, Yu‐Hsiang
Format: Artikel
Sprache:eng
Schlagworte:
Asthma
Bisphenol A
Cardiovascular diseases
Cell activation
Cyclooxygenase-2
Cytokines
Defence mechanisms
Diabetes mellitus
ERK‐NFκB
Extracellular signal-regulated kinase
Heart diseases
Immune response
Immune system
Immunity
Infectious diseases
Innate immunity
JAK1/2‐STAT3
Janus kinase
Janus kinase 2
Macrophages
MAP kinase
NF-κB protein
Nitric-oxide synthase
Nuclear transport
Phenols
Phosphorylation
proinflammatory mediators
Prostaglandin E2
Stat1 protein
Stat3 protein
Translocation
Tumor necrosis factor-α
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Zusammenfassung:Macrophages not only play an important role in the innate immune response but also participate in many inflammatory and infectious diseases including asthma, diabetes, obesity, cardiovascular diseases, and cancers. Bisphenol A (BPA) is the most commonly used component for plastic products. However, BPA is an endocrine disruptor for mammals and participates in several inflammatory and infectious diseases. Up until now, there are no researches demonstrated the potential role of BPA in macrophage activation and its relative mechanism. BPA promoted the generation of proinflammatory cytokines IL‐1β, IL‐6, and TNFα in a concentration‐dependent manner (P 
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.22702