Enhanced treatment effect of nanoparticles containing cisplatin and a GSH-reactive probe compound

Cisplatin is a highly effective antitumor drug, which can kill cancer cells by crossing-linking DNA and inhibiting transcription, but this process is limited by the combination of cisplatin and many endogenous nucleophiles, such as glutathione (GSH). Thus, when cisplatin enter cells, it is potential...

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Veröffentlicht in:Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems Biomimetic Materials, Sensors and Systems, 2019-03, Vol.96, p.635-641
Hauptverfasser: Zhu, Ling-Jun, Gu, Lian-Shuai, Shi, Tian-Yi, Zhang, Xiang-Yang, Sun, Bai-Wang
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Sprache:eng
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