Enhanced treatment effect of nanoparticles containing cisplatin and a GSH-reactive probe compound
Cisplatin is a highly effective antitumor drug, which can kill cancer cells by crossing-linking DNA and inhibiting transcription, but this process is limited by the combination of cisplatin and many endogenous nucleophiles, such as glutathione (GSH). Thus, when cisplatin enter cells, it is potential...
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| Veröffentlicht in: | Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems Biomimetic Materials, Sensors and Systems, 2019-03, Vol.96, p.635-641 |
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| container_title | Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems |
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| creator | Zhu, Ling-Jun Gu, Lian-Shuai Shi, Tian-Yi Zhang, Xiang-Yang Sun, Bai-Wang |
| description | Cisplatin is a highly effective antitumor drug, which can kill cancer cells by crossing-linking DNA and inhibiting transcription, but this process is limited by the combination of cisplatin and many endogenous nucleophiles, such as glutathione (GSH). Thus, when cisplatin enter cells, it is potentially vulnerable to cytoplasmic inactivation by GSH. To settle this bottleneck, we designed and synthesized a probe compound (Probe 1) and fabricated pH-responsed cisplatin, Probe 1-loaded lipid-polymer hybrid NanoParticles (CPNPs) using a single-step sonication method. Probe 1 can specifically bind to GSH, thus avoiding the combination of GSH and cisplatin, and enhancing the pharmacological activity of cisplatin. In vitro studies have suggested CPNPs, compared with cisplatin, loaded lipid-polymer hybrid NanoParticles CNPs (Not contain Probe 1), could efficiently kill MCF-7 human breast cancer cells and A549 human nonsmall lung cancer cell. Hence, the CPNPs provided a new idea for treating cancer. |
| doi_str_mv | 10.1016/j.msec.2018.11.039 |
| format | Article |
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Thus, when cisplatin enter cells, it is potentially vulnerable to cytoplasmic inactivation by GSH. To settle this bottleneck, we designed and synthesized a probe compound (Probe 1) and fabricated pH-responsed cisplatin, Probe 1-loaded lipid-polymer hybrid NanoParticles (CPNPs) using a single-step sonication method. Probe 1 can specifically bind to GSH, thus avoiding the combination of GSH and cisplatin, and enhancing the pharmacological activity of cisplatin. In vitro studies have suggested CPNPs, compared with cisplatin, loaded lipid-polymer hybrid NanoParticles CNPs (Not contain Probe 1), could efficiently kill MCF-7 human breast cancer cells and A549 human nonsmall lung cancer cell. Hence, the CPNPs provided a new idea for treating cancer.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2018.11.039</identifier><identifier>PMID: 30606575</identifier><language>eng</language><publisher>Netherlands: Elsevier BV</publisher><subject>Anticancer properties ; Antitumor activity ; Breast cancer ; Cancer ; Cisplatin ; Deactivation ; Deoxyribonucleic acid ; DNA ; Glutathione ; Inactivation ; Lipids ; Lung cancer ; Materials science ; Nanoparticles ; Nucleophiles ; Pharmacology ; Polymers ; Sonication ; Transcription</subject><ispartof>Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, 2019-03, Vol.96, p.635-641</ispartof><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Mar 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-20eaae5c8a9f158c3c2f603267729dc003762297db3827aecb1739f65bdaf8143</citedby><cites>FETCH-LOGICAL-c331t-20eaae5c8a9f158c3c2f603267729dc003762297db3827aecb1739f65bdaf8143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30606575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Ling-Jun</creatorcontrib><creatorcontrib>Gu, Lian-Shuai</creatorcontrib><creatorcontrib>Shi, Tian-Yi</creatorcontrib><creatorcontrib>Zhang, Xiang-Yang</creatorcontrib><creatorcontrib>Sun, Bai-Wang</creatorcontrib><title>Enhanced treatment effect of nanoparticles containing cisplatin and a GSH-reactive probe compound</title><title>Materials Science & Engineering. 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In vitro studies have suggested CPNPs, compared with cisplatin, loaded lipid-polymer hybrid NanoParticles CNPs (Not contain Probe 1), could efficiently kill MCF-7 human breast cancer cells and A549 human nonsmall lung cancer cell. Hence, the CPNPs provided a new idea for treating cancer.</description><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cisplatin</subject><subject>Deactivation</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Glutathione</subject><subject>Inactivation</subject><subject>Lipids</subject><subject>Lung cancer</subject><subject>Materials science</subject><subject>Nanoparticles</subject><subject>Nucleophiles</subject><subject>Pharmacology</subject><subject>Polymers</subject><subject>Sonication</subject><subject>Transcription</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkc1O3TAQha2qVblAX6ALZKkbNkk9duKfJUIUkJBYUNaW44zbXCVOiB2kvn19xc-C1Wy-c2Y0HyHfgdXAQP7c11NCX3MGugaomTCfyA60EhUDA5_Jjhmuq8YIOCLHKe0Zk1oo_pUcCSaZbFW7I-4q_nXRY0_zii5PGDPFENBnOgcaXZwXt-bBj5ion2N2QxziH-qHtIwuD5G62FNHrx9uqpL3eXhGuqxzh4WelnmL_Sn5EtyY8NvrPCGPv65-X95Ud_fXt5cXd5UXAnLFGTqHrdfOBGi1F54HyQSXSnHTe8aEkpwb1XdCc-XQd6CECbLtehc0NOKEnL_0lvVPG6ZspyF5HEcXcd6S5SAbZgyXoqA_PqD7eVtjua5Qmumm5Y0qFH-h_DqntGKwyzpMbv1ngdmDALu3BwH2IMAC2CKghM5eq7duwv498vZx8R_lt4JY</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Zhu, Ling-Jun</creator><creator>Gu, Lian-Shuai</creator><creator>Shi, Tian-Yi</creator><creator>Zhang, Xiang-Yang</creator><creator>Sun, Bai-Wang</creator><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201903</creationdate><title>Enhanced treatment effect of nanoparticles containing cisplatin and a GSH-reactive probe compound</title><author>Zhu, Ling-Jun ; 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| subjects | Anticancer properties Antitumor activity Breast cancer Cancer Cisplatin Deactivation Deoxyribonucleic acid DNA Glutathione Inactivation Lipids Lung cancer Materials science Nanoparticles Nucleophiles Pharmacology Polymers Sonication Transcription |
| title | Enhanced treatment effect of nanoparticles containing cisplatin and a GSH-reactive probe compound |
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