Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR‐129‐5p axis

Timosaponin AIII (TSAIII) is a steroidal saponin that exerts anticancer activity on various cancer cells. In this study, we explore the effects of TSAIII on renal cell carcinoma (RCC) cells. Our findings show that TSAIII treatment (

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Veröffentlicht in:	Journal of cellular physiology 2019-08, Vol.234 (8), p.13332-13341
Hauptverfasser:	Chiang, Kuang‐Chung, Lai, Chung‐Yu, Chiou, Hui‐Ling, Lin, Chia‐Liang, Chen, Yong‐Syuan, Kao, Shao‐Hsuan, Hsieh, Yi‐Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Anticancer properties Antitumor activity Carcinoma, Renal Cell - drug therapy cathepsin C Cathepsins - genetics Cathepsins - metabolism Cell cycle Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Chromosome 5 Dipeptidyl-peptidase I Down-Regulation Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans invasion Kidney cancer Kinases Metastases migration Molecular Structure Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Pretreatment Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN protein Renal cell carcinoma Saponins - chemistry Saponins - pharmacology Steroids - chemistry Steroids - pharmacology timosaponin AIII (TSAIII)
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Zusammenfassung:	Timosaponin AIII (TSAIII) is a steroidal saponin that exerts anticancer activity on various cancer cells. In this study, we explore the effects of TSAIII on renal cell carcinoma (RCC) cells. Our findings show that TSAIII treatment (
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.28010