Novel Aminomethyl Derivatives of 4‐Methyl‐2‐prenylphenol: Synthesis and Antioxidant Properties

4‐Methyl‐2‐prenylphenol (1) was synthesized from para‐cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1. A comparative evaluation of their...

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Veröffentlicht in:Chemistry & biodiversity 2019-03, Vol.16 (3), p.e1800637-n/a
Hauptverfasser: Buravlev, Evgeny V., Fedorova, Irina V., Shevchenko, Oksana G., Kutchin, Aleksandr V.
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Sprache:eng
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Zusammenfassung:4‐Methyl‐2‐prenylphenol (1) was synthesized from para‐cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1. A comparative evaluation of their antioxidant properties was carried out using in vitro models. It was established that Mannich base with octylaminomethyl group has radical‐scavenging activity, high Fe2+‐chelation ability as well as the ability to inhibit oxidative hemolysis of red blood cells.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201800637