Novel Aminomethyl Derivatives of 4‐Methyl‐2‐prenylphenol: Synthesis and Antioxidant Properties
4‐Methyl‐2‐prenylphenol (1) was synthesized from para‐cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1. A comparative evaluation of their...
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Veröffentlicht in: | Chemistry & biodiversity 2019-03, Vol.16 (3), p.e1800637-n/a |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 4‐Methyl‐2‐prenylphenol (1) was synthesized from para‐cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1. A comparative evaluation of their antioxidant properties was carried out using in vitro models. It was established that Mannich base with octylaminomethyl group has radical‐scavenging activity, high Fe2+‐chelation ability as well as the ability to inhibit oxidative hemolysis of red blood cells. |
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ISSN: | 1612-1872 1612-1880 |
DOI: | 10.1002/cbdv.201800637 |