Impact of preoperative anxiety and depression on quality of life before and after resection of hepatocellular carcinoma

•HCC patients who have anxiety and depression symptoms (ADS) before surgery tend to have low post-surgery quality of life (QOL).•As hepatocellular carcinoma (HCC) therapies continueto evolve, many HCC survivors will need prompt intervention for the late effects of cancer.•ADS is a major health conce...

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Veröffentlicht in:Journal of affective disorders 2019-03, Vol.246, p.361-367
Hauptverfasser: Lee, Hao-Hsien, Chiu, Chong-Chi, Lin, Jin-Jia, Wang, Jhi-Joung, Lee, King-Teh, Sun, Ding-Ping, Shi, Hon-Yi
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Sprache:eng
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Zusammenfassung:•HCC patients who have anxiety and depression symptoms (ADS) before surgery tend to have low post-surgery quality of life (QOL).•As hepatocellular carcinoma (HCC) therapies continueto evolve, many HCC survivors will need prompt intervention for the late effects of cancer.•ADS is a major health concern for HCC patients, even for those who are well beyond the cancer treatment phase. For healthcare providers responsible for treating HCC patients, this study highlights the need for timely and appropriate poct-operative psychological care to minimize ADS in HCC cancer survivers. The impact of anxiety and depression symptoms (ADS) is often estimated in terms of clinical endpoints such as the risk of complications and probabilities of readmission and survival. The purpose of this study was to provide a benchmark for capturing the negative effects of ADS on quality of life after hepatocellular carcinoma (HCC) surgery and to provide an evidence base for future research and clinical interventions aimed at understanding and remediating these effects. This prospective study analyzed 410 HCC patients at three tertiary academic hospitals. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Functional Assessment of Cancer Therapy- Hepatobiliary (FACT-H) were administered before HCC surgery and at 6 months, 1 year, and 2 years after HCC surgery. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of ADS. At baseline, 9.0% of the participants had anxiety symptom (BAI > 10), 17.1% had depression symptom (BDI > 13), and 7.1% had ADS. Throughout the study period, anxiety and depression (differences-in-differences value) had significant (P 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2018.12.085