How I treat low von Willebrand factor levels

How I treat low von Willebrand factor levels

Partial quantitative deficiency of plasma von Willebrand factor (VWF) is responsible for the majority of cases of von Willebrand disease (VWD), the most common inherited human bleeding disorder. International consensus guidelines recommend that patients with reduced plasma VWF antigen (VWF:Ag) level...

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Veröffentlicht in:Blood 2019-02, Vol.133 (8), p.795-804
Hauptverfasser: Lavin, Michelle, O'Donnell, James S.
Format: Artikel
Sprache:eng
Schlagworte:
Elective Surgical Procedures
Female
Hemorrhage - blood
Hemorrhage - diagnosis
Hemorrhage - therapy
Humans
Male
Pregnancy
Pregnancy Complications, Hematologic - blood
Pregnancy Complications, Hematologic - diagnosis
Pregnancy Complications, Hematologic - therapy
von Willebrand Disease, Type 1 - blood
von Willebrand Disease, Type 1 - diagnosis
von Willebrand Disease, Type 1 - therapy
von Willebrand Factor - metabolism
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Zusammenfassung:Partial quantitative deficiency of plasma von Willebrand factor (VWF) is responsible for the majority of cases of von Willebrand disease (VWD), the most common inherited human bleeding disorder. International consensus guidelines recommend that patients with reduced plasma VWF antigen (VWF:Ag) levels and bleeding phenotypes be considered in 2 distinct subsets. First, patients with marked reductions in plasma VWF levels (
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2018-10-844936