Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma
Background To validate the newly proposed American Joint Committee on Cancer (AJCC) eighth edition staging in early T1 and T2 oral cavity cancers and its effect in predicting tumour control. Methods Retrospective analysis of treatment outcomes of 441 T1 to T2 oral squamous cell carcinoma (OSCC). Ove...
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| Veröffentlicht in: | Journal of surgical oncology 2019-03, Vol.119 (4), p.449-454 |
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| creator | Murthy, Samskruthi Low, Tsu‐Hui (Hubert) Subramaniam, Narayana Balasubramanian, Deepak Sivakumaran, Vidhyadharan Anand, Adharsh Vijayan, Smitha Nalumackal Nambiar, Ajit Thankappan, Krishnakumar Iyer, Subramania |
| description | Background
To validate the newly proposed American Joint Committee on Cancer (AJCC) eighth edition staging in early T1 and T2 oral cavity cancers and its effect in predicting tumour control.
Methods
Retrospective analysis of treatment outcomes of 441 T1 to T2 oral squamous cell carcinoma (OSCC). Overall survival (OS), disease‐specific survival (DSS), and tumour control were calculated and compared between the AJCC 7 and 8 staging systems.
Results
The 5‐year OS was 78% and 61% for T1 and T2 tumours, respetively (P |
| doi_str_mv | 10.1002/jso.25348 |
| format | Article |
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To validate the newly proposed American Joint Committee on Cancer (AJCC) eighth edition staging in early T1 and T2 oral cavity cancers and its effect in predicting tumour control.
Methods
Retrospective analysis of treatment outcomes of 441 T1 to T2 oral squamous cell carcinoma (OSCC). Overall survival (OS), disease‐specific survival (DSS), and tumour control were calculated and compared between the AJCC 7 and 8 staging systems.
Results
The 5‐year OS was 78% and 61% for T1 and T2 tumours, respetively (P < 0.001) (AJCC 7) vs 87% and 67% (P < 0.001) (AJCC 8). The 5‐year DSS was 78% and 61% for T1 and T2, respectively (P < 0.001) (AJCC 7) vs 89% and 71% (P < 0.001) (AJCC 8). For stages I and II tumours the 5‐year OS was 81% and 76%, respectively (P < 0.302) (AJCC 7) vs 87% and 73% (P < 0.017) (AJCC 8). The 5‐year DSS was 83% and 82% (P < 0.222) vs 89% and 77% (P < 0.016). With the AJCC eighth edition the 5‐year local, regional, and distant control rates for T1 vs T2 tumours were 85% vs 74% (P = 0.003), 95% vs 77% (P = 0.001), and 95% vs 80% (P = 0.014), respectively.
Conclusion
The AJCC 8th staging system provided for more accurate prediction of OS, DSS, and disease control in early oral cavity cancers.]]></description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.25348</identifier><identifier>PMID: 30575027</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; American Joint Committee for Cancer 8 ; Cancer surgery ; depth of invasion ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Neoplasm Staging ; Oral cancer ; Retrospective Studies ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - mortality ; Squamous Cell Carcinoma of Head and Neck - pathology ; Tongue ; tongue cancer ; Tumors</subject><ispartof>Journal of surgical oncology, 2019-03, Vol.119 (4), p.449-454</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3538-82e8275396063523bcff49f77997d9ec89585eb37e0f6fd862abc681fd9abeb83</citedby><cites>FETCH-LOGICAL-c3538-82e8275396063523bcff49f77997d9ec89585eb37e0f6fd862abc681fd9abeb83</cites><orcidid>0000-0001-7404-1452</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.25348$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.25348$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30575027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murthy, Samskruthi</creatorcontrib><creatorcontrib>Low, Tsu‐Hui (Hubert)</creatorcontrib><creatorcontrib>Subramaniam, Narayana</creatorcontrib><creatorcontrib>Balasubramanian, Deepak</creatorcontrib><creatorcontrib>Sivakumaran, Vidhyadharan</creatorcontrib><creatorcontrib>Anand, Adharsh</creatorcontrib><creatorcontrib>Vijayan, Smitha Nalumackal</creatorcontrib><creatorcontrib>Nambiar, Ajit</creatorcontrib><creatorcontrib>Thankappan, Krishnakumar</creatorcontrib><creatorcontrib>Iyer, Subramania</creatorcontrib><title>Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description><![CDATA[Background
To validate the newly proposed American Joint Committee on Cancer (AJCC) eighth edition staging in early T1 and T2 oral cavity cancers and its effect in predicting tumour control.
Methods
Retrospective analysis of treatment outcomes of 441 T1 to T2 oral squamous cell carcinoma (OSCC). Overall survival (OS), disease‐specific survival (DSS), and tumour control were calculated and compared between the AJCC 7 and 8 staging systems.
Results
The 5‐year OS was 78% and 61% for T1 and T2 tumours, respetively (P < 0.001) (AJCC 7) vs 87% and 67% (P < 0.001) (AJCC 8). The 5‐year DSS was 78% and 61% for T1 and T2, respectively (P < 0.001) (AJCC 7) vs 89% and 71% (P < 0.001) (AJCC 8). For stages I and II tumours the 5‐year OS was 81% and 76%, respectively (P < 0.302) (AJCC 7) vs 87% and 73% (P < 0.017) (AJCC 8). The 5‐year DSS was 83% and 82% (P < 0.222) vs 89% and 77% (P < 0.016). With the AJCC eighth edition the 5‐year local, regional, and distant control rates for T1 vs T2 tumours were 85% vs 74% (P = 0.003), 95% vs 77% (P = 0.001), and 95% vs 80% (P = 0.014), respectively.
Conclusion
The AJCC 8th staging system provided for more accurate prediction of OS, DSS, and disease control in early oral cavity cancers.]]></description><subject>Adult</subject><subject>Aged</subject><subject>American Joint Committee for Cancer 8</subject><subject>Cancer surgery</subject><subject>depth of invasion</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Staging</subject><subject>Oral cancer</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - mortality</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>Tongue</subject><subject>tongue cancer</subject><subject>Tumors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMoun4c_AMS8KKHapo0TXKUxU8ED65eS5pOdrO0jSYtsv_erKseBE8DM888vLwIHefkIieEXi6jv6CcFXILTXKiykwRJbfRJN1oVghF9tB-jEtCiFJlsYv2GOGCEyomyLzq1jV6cL7H3uJhARjcfDEsMDTua3v1MJ3iOOi56-c4ruIAHXY9Bh3aFZ7lePB4RrEPusXxfdSdHyM20LbY6GBc7zt9iHasbiMcfc8D9HJzPZveZY9Pt_fTq8fMMM5kJilIKjhTJSkZp6w21hbKCqGUaBQYqbjkUDMBxJa2kSXVtSllbhula6glO0BnG-9b8O8jxKHqXFxH0T2kVBXNuVKSppeEnv5Bl34MfUqXKMkKwWW-Fp5vKBN8jAFs9RZcp8Oqykm1br5KzVdfzSf25Ns41h00v-RP1Qm43AAfroXV_6bq4flpo_wEyzOLug</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Murthy, Samskruthi</creator><creator>Low, Tsu‐Hui (Hubert)</creator><creator>Subramaniam, Narayana</creator><creator>Balasubramanian, Deepak</creator><creator>Sivakumaran, Vidhyadharan</creator><creator>Anand, Adharsh</creator><creator>Vijayan, Smitha Nalumackal</creator><creator>Nambiar, Ajit</creator><creator>Thankappan, Krishnakumar</creator><creator>Iyer, Subramania</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7404-1452</orcidid></search><sort><creationdate>201903</creationdate><title>Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma</title><author>Murthy, Samskruthi ; Low, Tsu‐Hui (Hubert) ; Subramaniam, Narayana ; Balasubramanian, Deepak ; Sivakumaran, Vidhyadharan ; Anand, Adharsh ; Vijayan, Smitha Nalumackal ; Nambiar, Ajit ; Thankappan, Krishnakumar ; Iyer, Subramania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3538-82e8275396063523bcff49f77997d9ec89585eb37e0f6fd862abc681fd9abeb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>American Joint Committee for Cancer 8</topic><topic>Cancer surgery</topic><topic>depth of invasion</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Staging</topic><topic>Oral cancer</topic><topic>Retrospective Studies</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - mortality</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>Tongue</topic><topic>tongue cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murthy, Samskruthi</creatorcontrib><creatorcontrib>Low, Tsu‐Hui (Hubert)</creatorcontrib><creatorcontrib>Subramaniam, Narayana</creatorcontrib><creatorcontrib>Balasubramanian, Deepak</creatorcontrib><creatorcontrib>Sivakumaran, Vidhyadharan</creatorcontrib><creatorcontrib>Anand, Adharsh</creatorcontrib><creatorcontrib>Vijayan, Smitha Nalumackal</creatorcontrib><creatorcontrib>Nambiar, Ajit</creatorcontrib><creatorcontrib>Thankappan, Krishnakumar</creatorcontrib><creatorcontrib>Iyer, Subramania</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murthy, Samskruthi</au><au>Low, Tsu‐Hui (Hubert)</au><au>Subramaniam, Narayana</au><au>Balasubramanian, Deepak</au><au>Sivakumaran, Vidhyadharan</au><au>Anand, Adharsh</au><au>Vijayan, Smitha Nalumackal</au><au>Nambiar, Ajit</au><au>Thankappan, Krishnakumar</au><au>Iyer, Subramania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2019-03</date><risdate>2019</risdate><volume>119</volume><issue>4</issue><spage>449</spage><epage>454</epage><pages>449-454</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract><![CDATA[Background
To validate the newly proposed American Joint Committee on Cancer (AJCC) eighth edition staging in early T1 and T2 oral cavity cancers and its effect in predicting tumour control.
Methods
Retrospective analysis of treatment outcomes of 441 T1 to T2 oral squamous cell carcinoma (OSCC). Overall survival (OS), disease‐specific survival (DSS), and tumour control were calculated and compared between the AJCC 7 and 8 staging systems.
Results
The 5‐year OS was 78% and 61% for T1 and T2 tumours, respetively (P < 0.001) (AJCC 7) vs 87% and 67% (P < 0.001) (AJCC 8). The 5‐year DSS was 78% and 61% for T1 and T2, respectively (P < 0.001) (AJCC 7) vs 89% and 71% (P < 0.001) (AJCC 8). For stages I and II tumours the 5‐year OS was 81% and 76%, respectively (P < 0.302) (AJCC 7) vs 87% and 73% (P < 0.017) (AJCC 8). The 5‐year DSS was 83% and 82% (P < 0.222) vs 89% and 77% (P < 0.016). With the AJCC eighth edition the 5‐year local, regional, and distant control rates for T1 vs T2 tumours were 85% vs 74% (P = 0.003), 95% vs 77% (P = 0.001), and 95% vs 80% (P = 0.014), respectively.
Conclusion
The AJCC 8th staging system provided for more accurate prediction of OS, DSS, and disease control in early oral cavity cancers.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30575027</pmid><doi>10.1002/jso.25348</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7404-1452</orcidid></addata></record> |
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| ispartof | Journal of surgical oncology, 2019-03, Vol.119 (4), p.449-454 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged American Joint Committee for Cancer 8 Cancer surgery depth of invasion Female Humans Male Middle Aged Mouth Neoplasms - mortality Mouth Neoplasms - pathology Neoplasm Staging Oral cancer Retrospective Studies Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - mortality Squamous Cell Carcinoma of Head and Neck - pathology Tongue tongue cancer Tumors |
| title | Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma |
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