Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis

Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis

A subset of infants are hypersusceptible to severe/acute viral bronchiolitis (AVB), for reasons incompletely understood. To characterize the cellular/molecular mechanisms underlying infant AVB in circulating cells/local airway tissues. Peripheral blood mononuclear cells and nasal scrapings were obta...

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Veröffentlicht in:American journal of respiratory and critical care medicine 2019-06, Vol.199 (12), p.1537-1549
Hauptverfasser: Jones, Anya C, Anderson, Denise, Galbraith, Sally, Fantino, Emmanuelle, Gutierrez Cardenas, Diana, Read, James F, Serralha, Michael, Holt, Barbara J, Strickland, Deborah H, Sly, Peter D, Bosco, Anthony, Holt, Patrick G
Format: Artikel
Sprache:eng
Schlagworte:
Age
Asthma
Binomial distribution
Bronchiolitis, Viral - genetics
Bronchiolitis, Viral - immunology
Child, Preschool
Children & youth
Data analysis
Female
Genes
Humans
Immunity, Innate
Infant
Infant, Newborn
Infections
Influenza
Leukocytes, Mononuclear - immunology
Male
Nasal Mucosa - immunology
Phenotype
Principal components analysis
Quality control
Respiratory syncytial virus
Sequence Analysis, RNA
Transcriptome
Viral infections
Viruses
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Beschreibung
Zusammenfassung:A subset of infants are hypersusceptible to severe/acute viral bronchiolitis (AVB), for reasons incompletely understood. To characterize the cellular/molecular mechanisms underlying infant AVB in circulating cells/local airway tissues. Peripheral blood mononuclear cells and nasal scrapings were obtained from infants (
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201804-0715OC