Visible-light-promoted oxidation/condensation of benzyl alcohols with dialkylacetamides to cinnamides

Visible-light-promoted oxidation/condensation of benzyl alcohols with dialkylacetamides to cinnamides

Oxidative cross-coupling reactions of benzyl alcohols with N,N-dialkylacetamides were developed only employing oxygen as the terminal oxidant, efficiently providing a new, novel protocol for the construction of multifunctionalized cinnamides with the synergistic effects of KOH, organic photocatalyst...

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Veröffentlicht in:Organic & biomolecular chemistry 2019-01, Vol.17 (3), p.449-453
Hauptverfasser: Yang, Tianlong, Lu, Maojian, Lin, Zhaowei, Huang, Mingqiang, Cai, Shunyou
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Alcohols
Benzyl alcohol
Chemical reactions
Cross coupling
Irradiation
Light irradiation
Oxidation
Substrates
Synergistic effect
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Zusammenfassung:Oxidative cross-coupling reactions of benzyl alcohols with N,N-dialkylacetamides were developed only employing oxygen as the terminal oxidant, efficiently providing a new, novel protocol for the construction of multifunctionalized cinnamides with the synergistic effects of KOH, organic photocatalyst eosin Y, and visible light irradiation at room temperature. A broad substrate scope and mild reaction conditions are the prominent features of this transformation.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02938e