Total Synthesis of Herquline B and C

Total Synthesis of Herquline B and C

The total syntheses of (−)-herquline B (2) and a heretofore-unrecognized congener, (+)-herquline C (3), are described. The syntheses require 14 and 13 steps, respectively, and feature a key oxazoline reduction that sets the stage for piperazine construction.

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Veröffentlicht in:Journal of the American Chemical Society 2019-01, Vol.141 (1), p.25-28
Hauptverfasser: Cox, Joshua B, Kimishima, Aoi, Wood, John L
Format: Artikel
Sprache:eng
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Zusammenfassung:The total syntheses of (−)-herquline B (2) and a heretofore-unrecognized congener, (+)-herquline C (3), are described. The syntheses require 14 and 13 steps, respectively, and feature a key oxazoline reduction that sets the stage for piperazine construction.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b10212