Phase Separation, Protein Disorder, and Enhancer Function

New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dyna...

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Veröffentlicht in:Cell 2018-12, Vol.175 (7), p.1723-1725
1. Verfasser: Hahn, Steven
Format: Artikel
Sprache:eng
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Zusammenfassung:New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dynamic low-specificity interactions within the complex. New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dynamic low-specificity interactions within the complex.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2018.11.034