Diagnosis of penicillin allergy: a MOFs-based composite hydrogel for detecting β-lactamase in serum

An as-synthesized MOFs-based hydrogel exhibits high sensitivity for β-lactamase through an "ON-OFF-OFF-ON" luminescence trigger. It allows achieving an unprecedented strategy for the judgement of penicillin allergy via luminescence detection of β-lactamase in serum.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019, Vol.55 (2), p.241-244
Hauptverfasser:	Lian, Xiao, Yan, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates - chemistry Antibiotics beta-Lactamases - blood beta-Lactamases - chemistry Drug Hypersensitivity - diagnosis Drug Hypersensitivity - etiology Europium - chemistry Humans Hydrogels Hydrogels - chemical synthesis Hydrogels - chemistry Hydrogels - radiation effects Iron - chemistry Limit of Detection Luminescence Luminescent Agents - chemical synthesis Luminescent Agents - chemistry Luminescent Agents - radiation effects Luminescent Measurements - methods Metal-Organic Frameworks - chemical synthesis Metal-Organic Frameworks - chemistry Metal-Organic Frameworks - radiation effects Penicillamine - chemical synthesis Penicillamine - chemistry Penicillin Penicillins - adverse effects Penicillins - chemistry
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Beschreibung
Zusammenfassung:	An as-synthesized MOFs-based hydrogel exhibits high sensitivity for β-lactamase through an "ON-OFF-OFF-ON" luminescence trigger. It allows achieving an unprecedented strategy for the judgement of penicillin allergy via luminescence detection of β-lactamase in serum.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c8cc08245f