New tetrahydroquinoline and indoline compounds containing a hydroxy cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504
Two new antibiotics, designated virantmycin B ( 1 ) and C ( 2 ), were isolated from the cultured broth of Streptomyces sp. AM-2504. Compounds 1 and 2 were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. The chemical struct...
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Veröffentlicht in: | Journal of antibiotics 2019-03, Vol.72 (3), p.169-173 |
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Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Two new antibiotics, designated virantmycin B (
1
) and C (
2
), were isolated from the cultured broth of
Streptomyces
sp. AM-2504. Compounds
1
and
2
were purified by Diaion HP-20, silica gel, and octadecylsilane chromatography, followed by high-performance liquid chromatography. The chemical structures of the new compounds,
1
and
2
, were determined by nuclear magnetic resonance and mass spectrometry, as containing a terahydroquinoline and an indoline, respectively, each also containing a hydroxy cyclopentenone moiety. Both compounds demonstrated weak antimicrobial (both antibacterial and antifungal) activity and compound
1
also showed antiviral activity against the dengue virus, whereas compound
2
exhibited no antiviral properties. |
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ISSN: | 0021-8820 1881-1469 |
DOI: | 10.1038/s41429-018-0117-0 |