Regulated on activation, normal T cell expressed and secreted and tumor necrosis factor-[alpha] in septic neonates

Measuring serum tumour necrosis factor-alpha (TNF-alpha) and Regulated upon Activation Normal T cell Expressed and Secreated (RANTES) in neonatal sepsis and determining whether early and late onset sepsis were associated with differences in their concentrations. In 15 neonates showing clinical signs...

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Veröffentlicht in:Journal of perinatology 2010-03, Vol.30 (3), p.192-196
Hauptverfasser: Shouman, B, Badr, R
Format: Artikel
Sprache:eng
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Zusammenfassung:Measuring serum tumour necrosis factor-alpha (TNF-alpha) and Regulated upon Activation Normal T cell Expressed and Secreated (RANTES) in neonatal sepsis and determining whether early and late onset sepsis were associated with differences in their concentrations. In 15 neonates showing clinical signs of early- or late-onset infection, serum TNF-alpha and RANTES were determined at first suspicion of sepsis and before starting antibiotics. Fifteen healthy neonates were included as controls. Serum TNF-alpha white blood cells and C-reactive protein (CRP) were significantly higher, whereas RANTES was significantly lower in the septic group compared with the non-septic group. There was no significant difference in RANTES or TNF-alpha levels between infants having early or late-onset sepsis. Similar to term neonates, premature neonates, responded to infection with increased TNF-alpha and decreased RANTES, with no statistical differences between both groups. In this study TNF-alpha is the best diagnostic test of neonatal sepsis, followed by CRP, when evaluated at first suspicion of sepsis.
ISSN:0743-8346
1476-5543
DOI:10.1038/jp.2009.167