Prognostic value of difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock: a pilot study

To evaluate the prognostic value of the difference between peripheral venous and arterial partial pressure of carbon dioxide in patients with septic shock following early resuscitation. This prospective study was conducted among the patients with septic shock treated in our department during the period from May, 2017 to May, 2018. Peripheral venous, peripheral arterial and central venous blood samples were collected simultaneously and analyzed immediately at bedside after 6-h bundle treatment. Arterial blood lactate concentration (Lac) and the arterial (PaCO ), peripheral venous (PpvCO ) and central venous partial pressure of carbon dioxide (PcvCO ) were recorded. The differences between PpvCO and PaCO (Ppv-aCO ) and between PcvCO and PaCO (Pcv-aCO ) were calculated. Pearson correlation analysis was used to test the agreement between Pcv-aCO and Ppv-aCO . Multivariable logistic regression analysis was performed to analyze the possible risk factors for 28-day mortality, and the receiver-operating characteristi