Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation

Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation

Iron-catalyzed hydrosilylation of imines to amines using a well-defined iron complex is reported. This method employs relatively mild conditions, by reaction of imine, (EtO)3SiH in a 1 : 2 ratio in the presence of 1 mol% precatalyst ([BIAN]Fe(η6-toluene), 3, BIAN = bis(2,6-diisopropylaniline)acenaph...

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Veröffentlicht in:Organic & biomolecular chemistry 2018-12, Vol.16 (48), p.9368-9372
Hauptverfasser: Saini, Anu, Smith, Cecilia R, Wekesa, Francis S, Helms, Amanda K, Findlater, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Acenaphthene
Amines
Hydrosilylation
Imines
Iron
Toluene
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Zusammenfassung:Iron-catalyzed hydrosilylation of imines to amines using a well-defined iron complex is reported. This method employs relatively mild conditions, by reaction of imine, (EtO)3SiH in a 1 : 2 ratio in the presence of 1 mol% precatalyst ([BIAN]Fe(η6-toluene), 3, BIAN = bis(2,6-diisopropylaniline)acenaphthene) at 70 °C. A broad scope of imines was readily converted into the corresponding secondary amines without the need for precatalyst activators.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob01262h