Pharmacological explorations of eco‐friendly amide substituted (Z)‐β‐enaminones as anti‐breast cancer drugs

Amide substituted (Z)‐β‐enaminones were synthesized by green chemistry and stereo‐specific synthetic pathway as novel phosphoinositide 3‐kinase (PI3K) inhibitors and breast cancer drugs. PI3K inhibition was measured by competitive ELISA. A panel of cancer cell lines including MCF‐7 (breast cancer),...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2019-01, Vol.352 (1), p.e1800244-n/a
Hauptverfasser:	Subramamiam, Palaniraja, Ramasubbu, Chandrasekaran, Athiramu, Selvaraj, Arumugam, Sivakumar, Alagumuthu, Manikandan
Format:	Artikel
Sprache:	eng
Schlagworte:	amide substituted (Z)‐β‐enaminones anticancer Breast cancer Colorectal cancer molecular docking phosphoinositide 3‐kinase SAR Skin cancer
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Zusammenfassung:	Amide substituted (Z)‐β‐enaminones were synthesized by green chemistry and stereo‐specific synthetic pathway as novel phosphoinositide 3‐kinase (PI3K) inhibitors and breast cancer drugs. PI3K inhibition was measured by competitive ELISA. A panel of cancer cell lines including MCF‐7 (breast cancer), G‐361 (skin cancer), and HCT 116 (colon cancer) were used to assess the anticancer potentials. In the PI3K assay, 2c and 2f were indolent for the proposed inhibitory action, which was recognized from the obtained IC50 (>1.0 μM). Excellent activity potential of 2a, 2b, and 2d was recognized from the IC50 range (
ISSN:	0365-6233 1521-4184
DOI:	10.1002/ardp.201800244