Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges

The recent emergence of numerous nanotechnologies is expected to facilitate the development of regenerative medicine, which is a tissue regeneration technique based on the replacement/repair of diseased tissue or organs to restore the function of lost, damaged, and aging cells in the human body. In particular, the unique magnetic properties and specific dimensions of magnetic nanomaterials make them promising innovative components capable of significantly advancing the field of tissue regeneration. Their potential applications in tissue regeneration are the focus here, beginning with the fundamentals of magnetic nanomaterials. How nanomaterials—both those that are intrinsically magnetic and those that respond to an externally applied magnetic field—can enhance the efficiency of tissue regeneration is also described. Applications including magnetically controlled cargo delivery and release, real‐time visualization and tracking of transplanted cells, magnetic regulation of cell proliferation/differentiation, and magnetic activation of targeted ion channels and signal pathways involved in regeneration are highlighted, and comments on the perspectives and challenges in magnetic nanomaterial‐based tissue regeneration are given. The potential applications of magnetic nanomaterials in tissue regeneration are summarized. Utilization of the distinctive properties of magnetic nanomaterials in promoting tissue regeneration is highlighted, and recent advances in understanding the role of magnetic nanomaterials in regenerative medicine are discussed along with perspectives and challenges in magnetic‐nanomaterial‐based tissue regeneration.