In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis
Antiprotozoal activity of 36 medicinal plants was evaluated. potency against , , and beside cytotoxicity on MRC-5 fibroblasts were determined. showed the highest activity against (IC of 0.6 μg/ml) and (IC of 0.5 μg/ml) with low cytotoxicity (CC of 30 μg/ml). and , showed pronounced potency against w...
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| Veröffentlicht in: | Future medicinal chemistry 2018-11, Vol.10 (22), p.2607-2617 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Antiprotozoal activity of 36 medicinal plants was evaluated.
potency against
,
,
and
beside cytotoxicity on MRC-5 fibroblasts were determined.
showed the highest activity against
(IC
of 0.6 μg/ml) and
(IC
of 0.5 μg/ml) with low cytotoxicity (CC
of 30 μg/ml).
and
, showed pronounced potency against
with an IC
of 3.6 and 2.5 μg/ml, respectively.
and
exhibited pronounced activity toward
with an IC
of 3.2 and 2.0 μg/ml, respectively.
,
c
,
,
and
showed relevant selectivity. |
|---|---|
| ISSN: | 1756-8919 1756-8927 |
| DOI: | 10.4155/fmc-2018-0180 |