Peripheral nerve targeting by procaine-conjugated ribavirin-loaded dual drug nanovesicle

Procaine that is able to reach the peripheral nervous system (PNS) was conjugated as a ligand with lipid nanovesicle and loaded with ribavirin (a broad spectrum antiviral drug incapable of entering the PNS on its own) to target the PNS with a dual-drug effect. Different physicochemical characterizations, γ-scintigraphy and electromyography of the developed nanovesicle were conducted. Marked capability of the optimized radiolabeled formulation to target PNS was observed in rats. Electromyography signals were reduced after treatment with the formulation on conscious rats. The developed nanocarrier can deliver drug successfully at the PNS and reduce excitation of the nerve and thus give a better therapeutic option for treatment of various diseases and disorders of the PNS.