The impact of malignancy on response to ovarian stimulation for fertility preservation: a meta-analysis

To evaluate the impact of cancer diagnosis on response to ovarian stimulation for fertility preservation. Meta-analysis. Not applicable. An electronic-based search was performed with the use of PubMed until May 2018 limited to English-language articles. In the final analysis, 10 case-controlled retrospective cohort studies were included, comparing ovarian response to stimulation between women with cancer and age-matched healthy women (control group). None. Number of total oocytes retrieved, number of mature oocytes, fertilization rate and two pronuclei embryos obtained. Ten studies that included a total of 713 women with cancer were analyzed in the cancer group (722 cycles), and 1,830 healthy women (1,835 cycles) qualified as controls for the meta-analysis. The pooled results showed no impact of cancer diagnosis on the mean number of total oocytes (P=.517; 95% CI −0.23 to 0.12), mature oocytes (P=.104; 95% CI −0.23 to 0.01), and two pronuclei embryos (P=.136; 95% CI −0.32 to 0.04) and fertilization rates (P=.273; 95% CI −0.29 to 0.183). When the analysis was limited to women with breast cancer diagnosis, there was also no difference in the mean number of total oocytes (P=.812; 95% CI −0.28 to 0.36) and mature oocytes (P=.993; 95% CI −0.16 to 0.16) between the two groups. This meta-analysis indicates that cancer diagnosis is not associated with reduced response to ovarian stimulation. El impacto del cáncer en la respuesta a la estimulación ováricapara la preservación de la fertilidad: un meta-análisis Evaluar el impacto del diagnóstico de cáncer en la respuesta a la estimulación ovárica para la preservación de la fertilidad. Meta-análisis. No aplicable. Se realizó una búsqueda electrónica con el uso de PubMed hasta mayo de 2018 limitada a artículos en inglés. En el análisis final, se incluyeron 10 estudios casos-control de cohortes retrospectivas, que compararon la respuesta ovárica a la estimulación entre mujeres con cáncer y mujeres sanas de la misma edad (grupo control). Ninguna. Número total de ovocitos recuperado, número de ovocitos maduros, tasa de fecundación y embriones obtenidos en estadio de 2 pronúcleos. Se analizaron diez estudios que incluyeron un total de 713 mujeres con cáncer en el grupo de cáncer (722 ciclos) y 1.830 mujeres sanas (1.835 ciclos) cuantificadas como controles para el meta-análisis. Los resultados combinados no mostraron impacto del diagnóstico de cáncer en el número medio de ovocitos totales (P=0.517; IC del 95% de -0.23 a 0.