Whole-Brain Radiotherapy (WBRT) for Brain Metastases: Does the Interval Between Imaging and Treatment Matter?

Many patients with brain metastases receive whole-brain radiotherapy (WBRT). An important question is whether a delay between diagnosis of brain metastases and treatment impairs the patient's prognosis. This retrospective study investigated the impact of the interval between diagnosis of brain...

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Veröffentlicht in:	Anticancer research 2018-12, Vol.38 (12), p.6835-6840
Hauptverfasser:	Hansen, Heinke C, Janssen, Stefan, Thieme, Cathrin, Perlov, Aleksej, Schild, Steven E, Rades, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Brain Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Clinical trials Cranial Irradiation - adverse effects Cranial Irradiation - methods Diagnosis Female Histology Humans Male Medical prognosis Metastases Metastasis Middle Aged Multivariate analysis Neuroimaging Neuroimaging - methods Patients Prognosis Radiation therapy Retrospective Studies Survival Analysis Time-to-Treatment Toxicity Treatment Outcome
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Zusammenfassung:	Many patients with brain metastases receive whole-brain radiotherapy (WBRT). An important question is whether a delay between diagnosis of brain metastases and treatment impairs the patient's prognosis. This retrospective study investigated the impact of the interval between diagnosis of brain metastases and WBRT plus ten additional factors on overall survival (OS) in 573 patients. Prospective trials cannot be performed due to ethical concerns. On univariate analyses, age (p
ISSN:	0250-7005 1791-7530
DOI:	10.21873/anticanres.13057