New Variant of CTX-M-Type Extended-Spectrum ?-Lactamases, CTX-M-71, with a Gly238Cys Substitution in a Klebsiella pneumoniae Isolate from Bulgaria

New Variant of CTX-M-Type Extended-Spectrum ?-Lactamases, CTX-M-71, with a Gly238Cys Substitution in a Klebsiella pneumoniae Isolate from Bulgaria

A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the ?-lactamas...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2009-10, Vol.53 (10), p.4518-4521
Hauptverfasser: Schneider, Ines, Queenan, Anne Marie, Markovska, Rumyana, Markova, Boyka, Keuleyan, Emma, Bauernfeind, Adolf
Format: Artikel
Sprache:eng
Schlagworte:
Klebsiella pneumoniae
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Zusammenfassung:A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the ?-lactamase for cefotaxime, ceftazidime, and cefepime.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00461-09