Radiosensitivity study of cefazolin sodium

Radiosensitivity study of cefazolin sodium

The extent of physico-chemical changes induced by irradiation of cefazolin sodium was investigated. The methods used were potency determination, impurity profile, colour measurements and pH measurements. The potency of irradiated samples at 25 kGy was 4 plus or minus 2% lower than that of the non ir...

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Veröffentlicht in:Talanta (Oxford) 2000-08, Vol.52 (2), p.873-877
Hauptverfasser: Crucq, A-S, Slegers, C, Deridder, V, Tilquin, B
Format: Artikel
Sprache:eng
Schlagworte:
Impurities
pH effects
Sterilization (cleaning)
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Zusammenfassung:The extent of physico-chemical changes induced by irradiation of cefazolin sodium was investigated. The methods used were potency determination, impurity profile, colour measurements and pH measurements. The potency of irradiated samples at 25 kGy was 4 plus or minus 2% lower than that of the non irradiated ones. The total amount of related substances increased from 0.72 plus or minus 0.01% in the non irradiated samples to 4.9 plus or minus 0.7% in the samples irradiated at 25 kGy. Most of the peaks showed trace amounts (
ISSN:0039-9140