Chloroperoxidase-catalyzed chlorination of didechloroaglucovancomycin and vancomycin

The chloroperoxidase (CPO) from Caldariomyces fumago catalyzed the chlorination of didechloroaglucovancomycin and vancomycin in the presence of hydrogen peroxide and chloride ion. Chlorination of didechloroaglucovancomycin has afforded new derivatives, with one and two chlorine atoms attached onto t...

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Veröffentlicht in:	Journal of molecular catalysis. B, Enzymatic Enzymatic, 2000-11, Vol.10 (6), p.545-549
Hauptverfasser:	Malnar, Ivica, Sih, Charles J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformations Chlorine compounds Chloroperoxidase Enzymatic chlorination Enzymes Fundamental and applied biological sciences. Psychology Hydrogen peroxide Methods. Procedures. Technologies Vancomycin
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Beschreibung
Zusammenfassung:	The chloroperoxidase (CPO) from Caldariomyces fumago catalyzed the chlorination of didechloroaglucovancomycin and vancomycin in the presence of hydrogen peroxide and chloride ion. Chlorination of didechloroaglucovancomycin has afforded new derivatives, with one and two chlorine atoms attached onto the aromatic ring of residue 7 of didechloroaglucovancomycin. Vancomycin was similarly chlorinated under the same conditions to furnish a new dichloro derivative.
ISSN:	1381-1177 1873-3158
DOI:	10.1016/S1381-1177(00)00002-3