Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports
We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a...
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| Veröffentlicht in: | Clinical infectious diseases 2008-08, Vol.47 (3), p.e36-e38 |
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| container_end_page | e38 |
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| container_issue | 3 |
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| container_title | Clinical infectious diseases |
| container_volume | 47 |
| creator | Gallagher, David P. Kieran, Jennifer Sheehan, Gerard Lambert, John Mahon, Niall Mallon, Patrick W. G. |
| description | We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia. |
| doi_str_mv | 10.1086/589869 |
| format | Article |
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G.</creatorcontrib><title>Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia.</description><subject>Adult</subject><subject>Atazanavir Sulfate</subject><subject>Drug Therapy, Combination</subject><subject>Electrocardiography - drug effects</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Protease Inhibitors - adverse effects</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Male</subject><subject>Methadone - therapeutic use</subject><subject>Middle Aged</subject><subject>Narcotics - therapeutic use</subject><subject>Oligopeptides - adverse effects</subject><subject>Pyridines - adverse effects</subject><subject>Ritonavir - therapeutic use</subject><subject>Tachycardia, Ventricular - chemically induced</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFLwzAYxvEgitOpH0HqxdOqSZM0qbc51AkTcQyRXcLbJGXVralJK85P73TDnTzlJfx4Dn-ETgi-IFiml1xmMs120AHhVMQpz8ju6sZcxkxS2UGHIbxiTIjEfB91iORcSiEP0GRcNq6Cj9LH186Fxpqo38AX_H71ogfbzMC4yvYiqEz0bKvGl7qdg48moGdLDd6UcBUl0QCCjca2dr4JR2ivgHmwx5u3iya3N5PBMB493t0P-qNYM8ya2GggRqRM88SYItO54BlwzBIKKdaCgsgZtQk1xlCRG6qtJEXBmNSYMkhoF52vZ2vv3lsbGrUog7bzOVTWtUElhFGSMr6F2rsQvC1U7csF-KUiWP3kU-t8K3i6WWzzhTVbtum1Amdr4Nr6_5F4bcpVzs8_Bf5NpYIKroYvUyVHKcd8-qQ4_QaJmoLi</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Gallagher, David P.</creator><creator>Kieran, Jennifer</creator><creator>Sheehan, Gerard</creator><creator>Lambert, John</creator><creator>Mahon, Niall</creator><creator>Mallon, Patrick W. 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G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>47</volume><issue>3</issue><spage>e36</spage><epage>e38</epage><pages>e36-e38</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. 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| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2008-08, Vol.47 (3), p.e36-e38 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Atazanavir Sulfate Drug Therapy, Combination Electrocardiography - drug effects HIV Infections - drug therapy HIV Protease Inhibitors - adverse effects Human immunodeficiency virus Humans Male Methadone - therapeutic use Middle Aged Narcotics - therapeutic use Oligopeptides - adverse effects Pyridines - adverse effects Ritonavir - therapeutic use Tachycardia, Ventricular - chemically induced |
| title | Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports |
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