Ritonavir-Boosted Atazanavir, Methadone, and Ventricular Tachycardia: 2 Case Reports

We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a...

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Veröffentlicht in:	Clinical infectious diseases 2008-08, Vol.47 (3), p.e36-e38
Hauptverfasser:	Gallagher, David P., Kieran, Jennifer, Sheehan, Gerard, Lambert, John, Mahon, Niall, Mallon, Patrick W. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atazanavir Sulfate Drug Therapy, Combination Electrocardiography - drug effects HIV Infections - drug therapy HIV Protease Inhibitors - adverse effects Human immunodeficiency virus Humans Male Methadone - therapeutic use Middle Aged Narcotics - therapeutic use Oligopeptides - adverse effects Pyridines - adverse effects Ritonavir - therapeutic use Tachycardia, Ventricular - chemically induced
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Zusammenfassung:	We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/589869