Electrostatic correlations fold DNA

Electrostatic correlations fold DNA

Electrostatic interactions have important effects on the physical properties of macromolecules such as DNA. DNA modeled as simple polyelectrolyte contain monomers with the same charge which can effectively attract each other due to electrostatic ion-ion correlations. This explains the phenomenon kno...

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Veröffentlicht in:BIOPOLYM 1999-02, Vol.49 (2), p.121-125
Hauptverfasser: Khan, Malek O., Jönsson, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Chemical bonds
Computer simulation
Condensation reactions
Conformations
Electrostatics
Macromolecules
Monte Carlo methods
Permittivity
Polyelectrolytes
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Zusammenfassung:Electrostatic interactions have important effects on the physical properties of macromolecules such as DNA. DNA modeled as simple polyelectrolyte contain monomers with the same charge which can effectively attract each other due to electrostatic ion-ion correlations. This explains the phenomenon known as DNA condensation. The condensation of DNA in vitro can be induced by a number of small polyvalent ions and by lowering the dielectric constant.
ISSN:0006-3525
1097-0282
DOI:10.1002/(SICI)1097-0282(199902)49:2<121::AID-BIP1>3.0.CO;2-2