In Vitro Study of the Modulatory Effects of Levofloxacin and BCG on Secretion of Proinflammatory Cytokines in Infiltrative Pulmonary Tuberculosis

The effects levofloxacin (fluoroquinolone) and vaccinal BCG strain on cytokine production by blood mononuclear leukocytes was studied in patients with infiltrative pulmonary tuberculosis. Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFα in drug-resistant...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-12, Vol.166 (2), p.225-228
Hauptverfasser:	Serebryakova, V. A., Urazova, O. I., Novitsky, V. V., Vengerovskii, A. I., Kononova, T. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - pharmacology Antibiotics Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - pharmacology Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology Drug Combinations Drug resistance Drug Resistance, Multiple, Bacterial Female Humans Inflammation Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin 12 Interleukin-12 - biosynthesis Interleukin-12 - immunology Interleukin-2 - biosynthesis Interleukin-2 - immunology Internal Medicine Laboratory Medicine Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - microbiology Levofloxacin Levofloxacin - pharmacology Male Middle Aged Mycobacterium bovis - cytology Mycobacterium bovis - immunology Mycobacterium tuberculosis - cytology Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Pathology Primary Cell Culture Tuberculosis Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-α γ-Interferon
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Beschreibung
Zusammenfassung:	The effects levofloxacin (fluoroquinolone) and vaccinal BCG strain on cytokine production by blood mononuclear leukocytes was studied in patients with infiltrative pulmonary tuberculosis. Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFα in drug-resistant pulmonary tuberculosis and production of IL-12 and IFNγ in drug-sensitive tuberculosis.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4319-z