Prophylactic use of probiotic chocolate modulates intestinal physiological functions in constipated rats

BACKGROUND This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 × 1010 CFU g−1 of probiotics daily for 4 weeks and treated with loperamide (5 mg kg−1) daily at the fourth week of treatment. RESULTS Probiotic c...

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Veröffentlicht in:	Journal of the science of food and agriculture 2019-04, Vol.99 (6), p.3045-3056
Hauptverfasser:	Lee, Chul Sang, Tan, Pei Lei, Eor, Ju Young, Choi, Da Hye, Park, Miri, Seo, Sung Keum, Yoon, Seokmin, Yang, Siyoung, Kim, Sae Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Animals Aquaporin 8 Bifidobacterium animalis - chemistry Bifidobacterium animalis - metabolism Chocolate Chocolate - analysis Chocolate - microbiology Colon Constipation Constipation - physiopathology Constipation - prevention & control Defecation - drug effects Feces - microbiology Female functional chocolate gastrointestinal function Gene expression Humans In vivo methods and tests intestinal barrier function Intestinal motility Intestine Intestines - physiopathology lactic acid bacteria Lactobacillus plantarum - chemistry Lactobacillus plantarum - physiology Moisture content Organic chemistry Polymerase chain reaction Probiotics Probiotics - administration & dosage Probiotics - chemistry Rats Rats, Sprague-Dawley Streptococcus thermophilus - chemistry Streptococcus thermophilus - physiology Water content
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Zusammenfassung:	BACKGROUND This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 × 1010 CFU g−1 of probiotics daily for 4 weeks and treated with loperamide (5 mg kg−1) daily at the fourth week of treatment. RESULTS Probiotic chocolate treatment significantly (P
ISSN:	0022-5142 1097-0010
DOI:	10.1002/jsfa.9518