Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay

Using DNA comet assay we found that polysaccharides from Tussilago farfara L . reduced the intensity of polychemotherapy-induced apoptosis and DNA damage in bone marrow cells and small intestinal epithelium of C57Bl/6 mice, which attested to genoprotective properties of these polysaccharides.

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-12, Vol.166 (2), p.217-221
Hauptverfasser:	Safonova, E. A., Lopatina, K. A., Vychuzhanina, A. V., Mashanova, V. A., Razina, T. G., Borovskaya, T. G., Zueva, E. P., Gur’ev, A. M., Belousov, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Combined Chemotherapy Protocols - antagonists & inhibitors Antineoplastic Combined Chemotherapy Protocols - toxicity Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Biology Cisplatin - antagonists & inhibitors Cisplatin - toxicity Comet Assay Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA damage Duodenum - cytology Duodenum - drug effects Duodenum - metabolism Epithelium Female Food irradiation Injections, Intraperitoneal Internal Medicine Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Irinotecan - antagonists & inhibitors Irinotecan - toxicity Laboratory Medicine Mice Mice, Inbred C57BL Paclitaxel - antagonists & inhibitors Paclitaxel - toxicity Pathology Plant Extracts - chemistry Polysaccharides Polysaccharides - isolation & purification Polysaccharides - pharmacology Tussilago - chemistry Tussilago farfara
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Beschreibung
Zusammenfassung:	Using DNA comet assay we found that polysaccharides from Tussilago farfara L . reduced the intensity of polychemotherapy-induced apoptosis and DNA damage in bone marrow cells and small intestinal epithelium of C57Bl/6 mice, which attested to genoprotective properties of these polysaccharides.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4317-1